2016
DOI: 10.3892/ijmm.2016.2736
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TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment

Abstract: T-box 18 (TBX18) plays a crucial role in the formation and development of the head of the sinoatrial node. The objective of this study was to induce adipose-derived stem cells (ADSCs) to produce pacemaker-like cells by transfection with the TBX18 gene. A recombinant adenovirus vector carrying the human TBX18 gene was constructed to transfect ADSCs. The ADSCs transfected with TBX18 were considered the TBX18-ADSCs. The control group was the GFP-ADSCs. The transfected cells were co-cultured with neonatal rat vent… Show more

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Cited by 26 publications
(30 citation statements)
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“…Accordingly, forced expression of TBX18 in hiPSC resulted in increased differentiation to SAN-like cardiomyocytes [21]. In addition, over-expresson of TBX18 could convert the human working cardiomyocytes, adult rat bone mesenchymal stem cell and adipose derived stem cells into functional SAN-like cardiomyocytes [22,23]. However, these methods of genetic manipulation for SAN regeneration are not desirable in future clinical applications.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, forced expression of TBX18 in hiPSC resulted in increased differentiation to SAN-like cardiomyocytes [21]. In addition, over-expresson of TBX18 could convert the human working cardiomyocytes, adult rat bone mesenchymal stem cell and adipose derived stem cells into functional SAN-like cardiomyocytes [22,23]. However, these methods of genetic manipulation for SAN regeneration are not desirable in future clinical applications.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, forced expression of TBX18 in hiPSC resulted in increased differentiation to SAN-like cardiomyocytes [21]. In addition, over-expression of TBX18 could convert the human working cardiomyocytes, adult rat bone mesenchymal stem cell and adipose-derived stem cells into functional SAN-like cardiomyocytes [22,23]. However, these methods of genetic manipulation for SAN regeneration are not desirable in the future clinical applications.…”
Section: Discussionmentioning
confidence: 99%
“…Systemic delivery of ASCs was applied in animal models of myocardial infarction ( Hong et al, 2014 ). In parallel, application of ASCs has been progressing as target differentiation of ASCs in vitro to produce desirable cell lines, i.e., into beating cardiomyocytes due to epigenetic modifications of human ASCs or their coculture with rodent cardiac cells ( Choi et al, 2010 ) and cardiac pacemakerlike cells due to transfection of rodent ASCs with TBX18 gene and their coculture with neonatal rodent cardiomyocytes ( Yang et al, 2016 ).…”
Section: Conclusion and Perspectives: Novel Vascular Engineering Stramentioning
confidence: 99%