TBX21 polymorphisms are associated with virus persistence in hepatitis C virus infection patients from a high-risk Chinese population

Abstract

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and the varied outcomes of the infection depend on both viral and host factors. We have demonstrated that the HCV alternate reading frame protein (F protein) is related to Th1/Th2 bias which is involved in virus persistence in chronic hepatitis C (CHC) patients. The purpose of this study was to test the hypothesis that genetic variants of TBX21 (T cell specific T-box transcription factor) were associated with the outcomes of HCV infection and F protein generation. Three single nucleotide polymorphisms (SNPs) (rs17250932, rs2074190, rs4794067) in the TBX21 gene were genotyped in a case-control study in a cohort of a high-risk group, including 354 healthy controls and 747 CHC patients (190 anti-F protein antibody seronegative patients and 557 anti-F protein antibody seropositive patients). Results showed that the rs4794067 C allele in the TBX21 promoter was significantly more common in CHC patients (OR = 1.335, 95% CI = 1.058-1.684, P = 0.015), exceptionally in anti-F protein seropositive patients (OR = 1.547, 95% CI = 1.140-2.101, P = 0.005), compared with healthy controls. And the risk effect was also significantly high in patients with HCV 1b genotype and mild fibrosis (P = 0.021, P = 0.010, respectively). Compared with the most frequent haplotype TAT, haplotype analysis showed that the distribution of TAC was significantly different between the chronic HCV carrier group and the healthy group, and so was the anti-F antibody seronegativity group and the anti-F antibody seronegativity group (all P < 0.001). Our results suggested that TBX21 variants may be involved in the etiology of this disease.

Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer

“…Correlation of genetic polymorphism has also been extensively studied in non-malignant diseases, as well as malignant diseases, and interestingly, were found to carry strong associations (18,20). According to the results of our study, there is no definitive evidence that laryngeal cancer is influenced by the polymorphisms of GLUT1, HIF1α, and TBX21.…”

Identification of potential mRNA panels for severe acute respiratory syndrome coronavirus 2 (COVID-19) diagnosis and treatment using microarray dataset and bioinformatics methods

“…Several studies have reported that enriched genes such as STAT5B (Mukherjee et al 2014), SOCS1 (Zheng et al 2015), CCR1 (Miller et al 2006) and CCL5 (Sali mi et al 2017) were highly expressed in respiratory syncytial virus infection, but elevated expression these genes may be involved in development of SARS-CoV-2 infection. Increasing evidence shows that the enriched genes such as IFNAR2 (Romporn et al 2013), TBX21 (Zhu et al 2015), GBP1 (Anderson et al 1999), IRF5 (Vandenbroeck et al 2011) and IFI35 (Estrabaud et al 2015) were over expressed in various viral infections, but high expression of these genes may be involved in infection of SARS-CoV-2 infection. Novel biomarkers such as IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon), TP53, CD247, IL18RAP, IL18R1, HRAS (HRas proto-oncogene, GTPase), PSMB9, IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta), ITGB2 and LTB4R were highly expressed and might be involved in progression of SARS-CoV-2 infection.…”