Tc-99m ethylenedicysteine and Tc-99m dimercaptosuccinic acid scintigraphy-comparison of the two for detection of scarring and differential cortical function

Abstract

Context:The differential cortical function obtained by Tc-99m EC is comparable to that of Tc-99m DMSA. However, identification of scars on Tc-99m EC images needs to be studied.Aims:The aim of the study is to evaluate role of Tc-99m EC for detection of scarring and differential cortical function by comparing with Tc-99m DMSA.Settings and Design:Prospective observational study of recurrent UTI; minimum 6 weeks after acute episode; when urine examination is negative for pus cells.Materials and Methods:Forty-seven children with normal positioned kidneys underwent Tc-99m EC and DMSA scintigraphy. The DRF and cortical phase images of both studies in the same image matrix size were evaluated by two independent observers for scarring; Tc-99m DMSA was considered as the gold standard.Statistical analysis used:MS Excel 2007 and GraphPad Instat V3.1 and ROC analysis.Results:There was no significant difference in the detection of scarring using two studies with Cohen's kappa coefficient (κ) 0.932. The sensitivity and specificity of Tc-99m EC for detection of scarring was 98.75% and 99.15%, respectively. There was good agreement between the differential cortical function calculated using two studies.Conclusions:The summed Tc-99m EC images with an acceptable high image contrast allow detection of cortical scarring in patients with normal kidney positions. It is an excellent single-modality comprehensive investigational agent for renal parenchymal defects, function, and excretion evaluation with the added advantages of lower cost, convenience, and low radiation exposure to the child.

The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy

“…In contrast, other authors did not show any correlation between urinary TGF-β1 and RRF [ 4 , 47 ]. In the present study, 99mTc-EC scintigraphy was used for renal scars assessment, which is an alternative to 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy, with high sensitivity (98.75%) and specificity (99.15%) for detection of scars in normally positioned kidneys but with lower radiation dose [ 61 ]. We demonstrated that approximately half of our children with advanced scars demonstrated tracer uptake higher than 45%.…”