Tc-99m-PEG-Liposomes Target Both Adhesions and Abscesses and Their Reduction by Hyaluronate in Rats With Fecal Peritonitis

Sikkink, C.J.J.M.; Reijnen, Michel M.P.J.; Laverman, Peter; Oyen, Wim J.G.; Goor, Harry van

doi:10.1016/j.jss.2008.07.018

Cited by 14 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…234,235 Radiolabelling studies have demonstrated that radiolabelled PEG-coated liposomes preferentially permeate into, and are specifically and selectively retained at, sites of infection. 49,50,236 Sikkink et al 237 later demonstrated a significant qualitative correlation between uptake of these particles and the size of intra-abdominal abscesses. The presence of an EPR effect in infection may rationalize these observations of selective accumulation at sites of infection.…”

Section: Jacmentioning

confidence: 99%

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

Azzopardi

Ferguson

Thomas

2012

Journal of Antimicrobial Chemotherapy

244

167

View full text Add to dashboard Cite

Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity, mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of macromolecular constructs, permitting increasingly selective targeting, alteration of volume of distribution and activity/toxicity. Macromolecules tend to passively and preferentially accumulate at sites of enhanced vascular permeability and are then retained. This enhanced permeability and retention (EPR) effect, whilst recognized as a major breakthrough in anti-tumoral targeting, has not yet been fully exploited in infection. Shared pathophysiological pathways in both cancer and infection are evident and a number of novel nanomedicines have shown promise in selective, passive, size-mediated targeting to infection. This review describes the similarities and parallels in pathophysiological pathways at molecular, cellular and circulatory levels between inflammation/infection and cancer therapy, where use of this principle has been established.

show abstract

Section: Jacmentioning

confidence: 99%

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

Azzopardi

Ferguson

Thomas

2012

Journal of Antimicrobial Chemotherapy

244

167

View full text Add to dashboard Cite

show abstract

“…Internal adhesions of the abdominal cavity resulting from peritonitis are one of the main sources of disease and death in dairy cattle (Cornelis et al 2009). Peritonitis, inflammation of the peritoneal cavity, may be localized or generalized and may be chronic or acute (Andrews et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Blood electrolytes changes in peritonitis of cattle

et al. 2011

View full text Add to dashboard Cite

Peritonitis is an inflammation of the peritoneal cavity and is one of the main causes of animal deaths. It has been reported that many diseases such as peritonitis cause electrolyte imbalance in the body. The present study has been conducted to evaluate the serum electrolyte concentration in cattle with peritonitis. In order to perform this study, 45 cattle with peritonitis were selected in the Karaj area, and 20 healthy cattle were used as the control group. After diagnosis of peritonitis in the infected cattle, 10-ml blood samples were taken from the jugular vein, the concentrations of calcium, phosphorus, magnesium, and chloride were estimated using the spectrophotometric method, and sodium and potassium concentrations were assessed by a flame photometer device. The results showed that the concentrations of calcium, magnesium, sodium, potassium, and chloride in cattle affected with peritonitis were reduced compared with the control group, but the differences were not statistically significant. The concentration of phosphorus in the peritonitis-infected cattle was significantly higher than in the healthy cattle. On the basis of the results of the present study, it can be concluded that inflammation of the peritoneal cavity in cattle causes blood electrolyte deterioration, and more attention needs to be focused on this factor in the treatment of infected animals.

show abstract

“…99 Tc-labelled proteins including aprotinin (6512 g/mol) allow rapid localisation around infected foci induced in vivo animal models (2 h), and their concentration was up to 6.5 times higher than control tissue (Komarek, Kleisner, Komarkova, et al, 2005). A correlation between intraabdominal abscesses and the magnitude of effect of EPR has also been reported with some compounds (Sikkink, Reijnen, Laverman, et al, 2009). Polymer therapeutics therefore presents the potential for a clinically feasible avenue to the management of multidrug-resistant surgical site infection.…”

Section: Targeted Antibiotic Delivery To Surgical Site Infectionsmentioning

confidence: 96%

“…In vitro breast cancer (Hardwicke, Ferguson, Moseley, et al, 2008b) Poloxamer Various In vivo preclinical phase (Medina et al, 2011;Sikkink et al, 2009) HA, hyaluronic acid; HPMA, N-(2-hydroxypropyl) methacrylamide.…”

Section: Succinoylated Dextrincolistinmentioning

confidence: 99%

Polymer therapeutics in surgery: the next frontier

Azzopardi

Conlan

Whitaker

2016

Journal of Interdisciplinary Nanomedicine

View full text Add to dashboard Cite

Polymer therapeutics is a successful branch of nanomedicine, which is now established in several facets of everyday practice. However, to our knowledge, no literature regarding the application of the underpinning principles, general safety, and potential of this versatile class to the perioperative patient has been published. This study provides an overview of polymer therapeutics applied to clinical surgery, including the evolution of this demand‐oriented scientific field, cutting‐edge concepts, its implications, and limitations, illustrated by products already in clinical use and promising ones in development. In particular, the effect of design of polymer therapeutics on biophysical and biochemical properties, the potential for targeted delivery, smart release, and safety are addressed. Emphasis is made on principles, giving examples in salient areas of demand in current surgical practice. Exposure of the practising surgeon to this versatile class is crucial to evaluate and maximise the benefits that this established field presents and to attract a new generation of clinician–scientists with the necessary knowledge mix to drive highly successful innovation.

show abstract

Tc-99m-PEG-Liposomes Target Both Adhesions and Abscesses and Their Reduction by Hyaluronate in Rats With Fecal Peritonitis

Cited by 14 publications

References 18 publications

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

Blood electrolytes changes in peritonitis of cattle

Polymer therapeutics in surgery: the next frontier

Contact Info

Product

Resources

About