Tc-99m Sestamibi Scintimammography in the Mammographically Dense Breast

Zegel, Harry G.; Heller, Lloyd; Edell, Steven L.; Squires, Fredric; Rubin, Jonathan

doi:10.1097/00003072-199912000-00013

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…These falsepositive readings might occur because of markedly increased metabolic activity, allowing accumulation of the radioisotope in these areas or because of the hypercellularity of the breast lesions with or without atypical cells. 2,11,13,16,17 There were two cases reported as false negative on SM examination that were diagnosed as malignant on histopathological examination. Of these cases, one proved to be infiltrating ductal carcinoma, which appeared as microcalcification on mammography without mass lesion, and the other was diagnosed as mucinous carcinoma, which looked like a cystic mass with an irregular thick wall on ultrasound (Table 3).…”

Section: Of the 25 Malignant Cases With 27 Lesions 25 Lesions (92%)mentioning

confidence: 99%

“…1 During the last decade, various studies have shown the use of scintimammography (SM) in evaluating patients with mammographically dense breasts, which present difficulties in interpreting mammograms. 2 The sensitivity of SM ranges from 60 to 96% and specificity ranges from 67 to 100%. 3,4 This technique is safe, easy to interpret and has excellent interobserver agreement.…”

Section: Introductionmentioning

confidence: 99%

“…Other causes of the false-positive results are epithelial hyperplasia, fibrocystic changes and sclerosing adenosis. These falsepositive readings might occur because of markedly increased metabolic activity, allowing accumulation of the radioisotope in these areas or because of the hypercellularity of the breast lesions with or without atypical cells 2,11,13,16,17. …”

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confidence: 99%

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Usefulness of scintimammography as an adjunct to mammography and ultrasound in the diagnosis of breast diseases

Gupta

Abdeen

Roberts

et al. 2006

Australasian Radiology

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This study was undertaken to evaluate the diagnostic efficacy of 99mtechnetium methoxyisobutylisonitrile scintimammography (SM) and combined use of mammography and ultrasound in the detection of the breast lesions in the symptomatic breast. Histopathological findings were the gold standard. Eighty patients with symptomatic breasts underwent mammography and/or ultrasound breast followed by SM. In 25 patients there were 27 lesions that were malignant and 55 patients had 65 lesions that were benign. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of SM were found to be 92, 72, 58, 96 and 78%, respectively, as compared with the combined use of mammography and ultrasound, which showed these parameters to be 89, 94, 86, 95 and 92%, respectively. In this study, SM showed slightly better sensitivity than combined mammography and ultrasound, whereas the specificity was clearly shown as higher in the latter.

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Section: Of the 25 Malignant Cases With 27 Lesions 25 Lesions (92%)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Usefulness of scintimammography as an adjunct to mammography and ultrasound in the diagnosis of breast diseases

Gupta

Abdeen

Roberts

et al. 2006

Australasian Radiology

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Diagnostic value of 99mTc MIBI scintimammography in patients with breast lesions

Yıldız

Çolak

Güngör

et al. 2001

Revista Española de Medicina Nuclear

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Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

Moriguchi¹,

Luca²,

Griva³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. Scintimammography using 99m tc-sestamibi is a noninvasive and painless diagnostic imaging method that is used to detect breast cancer when mammography is inconclusive. Because of the advantages of labeling with 99m Tc-sestamibi and its high efficiency in detecting carcinomas, it is the most widespread agent for this purpose. its accumulation in the tumor has multifactorial causes and does not depend on the presence of architectural distortion or local or diffuse density variation in the breast. the objective of this study was to evaluate the accuracy of scintimammography for detecting breast cancer. One hundred and fifty-seven patients presenting 158 palpable and non-palpable breast nodules were evaluated. three patients were male and 154 were female, aged between 14 and 81 years. all patients underwent scintimammography, and the nodule was subjected to cytological or histological study, i.e., the gold standard for diagnosing cancer. One hundred and eleven malignant and 47 benign nodules were detected, with predominance of ductal carcinomas (n=94) and fibroadenoma/fibrocystic condition (n=11/n=11), respectively. The mean size was 3.11 cm (7-10 cm) among the malignant nodules and 2.07 cm among the benign nodules (0.5-10 cm). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 89, 89, 95, 78 and 89%, respectively. analysis on the histological types showed that the technique was more effective on tumors that were more aggressive, such as ductal carcinoma. in this study, 99m tc-sestamibi scintimammography was shown to be an important tool for diagnosing breast cancer when mammography was inconclusive.Introduction mammography is the safest method for breast cancer screening (1-3). It presents good sensitivity for detecting palpable and non-palpable lesions and low specificity for distinguishing between benign and malignant processes (4). hence, a biopsy is often required for diagnostic confirmation (5). It also presents limitations in relation to detection of lesions in dense breasts (6-8). mann et al demonstrated that false negative mammograms cause delays in undertaking biopsies among patients with cancer (9). the high rates of unnecessary biopsies in cases of benign lesions (10) have encouraged research on non-invasive techniques with greater precision. ultrasound, magnetic resonance imaging, positron emission tomography and scintigraphy are important aids for detecting cancer when mammography is indeterminate (11). high-risk patients (e.g., family antecedents, atypical proliferative lesions and previous cancer subjected to tumorectomy or radiotherapy) have benefited from combined use of these methods (11). Scintigraphy is a noninvasive imaging examination that uses small doses of radiation (12). it is painless, its cost and availability are reasonable and it enables functional or metabolic evaluation of various organs or structures. its advantage is unequivocal, especially when analysis using other methods is limited, and it stands out as a diagnostic eva...

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Tc-99m Sestamibi Scintimammography in the Mammographically Dense Breast

Abstract: Six examples from our clinical experience show the usefulness of Tc-99m sestamibi imaging in patients with mammographically dense breasts. The ability to identify a malignancy or its absence supports the continued use of this procedure in these patients.

Cited by 3 publications

References 11 publications

Usefulness of scintimammography as an adjunct to mammography and ultrasound in the diagnosis of breast diseases

Usefulness of scintimammography as an adjunct to mammography and ultrasound in the diagnosis of breast diseases

Diagnostic value of 99mTc MIBI scintimammography in patients with breast lesions

Accuracy of 99mTc-sestamibi scintimammography for breast cancer diagnosis

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