Tc-99m Sestamibi Uptake by Malignant Lymphoma and Slow Washout

Matsui, Ritsuo; Komori, Tsuyoshi; Narabayashi, Isamu; Namba, Ryuuichiro; Nakata, Y; Tabuchi, Koujiro; Adachi, I; Tatu, Yoshimitu; Shimizu, Tadafumi; Sueyoshi, Kozo

doi:10.1097/00003072-199504000-00013

Cited by 24 publications

(1 citation statement)

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“…Although 99mTc-sestamibi was developed initially as an agent for MPI, several studies have shown that it accumulates in cardiac and extracardiac tissues, depending on the etiologic processes involved. An intense and discrete uptake of the radiotracer is commonly seen with viable tumors including thyroid ( 1 ), breast ( 2 , 3 ), lung cancers, lymphomas ( 4 , 5 , 6 ), musculoskeletal sarcomas ( 7 ), and carcinoid tumors ( 8 ); focal inflammatory processes and pulmonary thromboembolism (PE) ( 9 ) also demonstrate a similar uptake. On the other hand, a diffuse increase in the pulmonary uptake of 99m Tc sestamibi occurs in a variety of inflammatory and hypermetabolic processes affecting the myocardial and pulmonary tissues.…”

Section: Discussionmentioning

confidence: 99%

HIV-associated lymphocytic interstitial pneumonitis causes diffuse sestamibi lung uptake in myocardial perfusion imaging

Gadiraju¹,

Bommireddipalli²,

Rangray³

et al. 2009

Radiology Case Reports

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Technetium-99m (99mTc) sestamibi myocardial perfusion scintigraphy (MPI) is widely used for the diagnosis and assessment of prognosis in patients with suspected coronary artery disease. During these investigations, inspection of raw projected data for the purpose of quality control may occasionally yield incidental noncardiac findings that suggest the presence of another primary noncardiac disease. We present a 66-year-old HIV patient with a tissue diagnosis of lymphoid interstitial pneumonitis (LIP), who demonstrated a diffuse increase of 99mTc sestamibi in bilateral lung fields both in rest and stress MPI.

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