TCDD-Inducible Poly(ADP-ribose) Polymerase: A Novel Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Ma, Qiang; Baldwin, Kimberly T.; Renzelli, Anthony J.; McDaniel, Alison; Dong, Liquin

doi:10.1006/bbrc.2001.5987

Cited by 129 publications

(96 citation statements)

References 38 publications

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“…However, it is unclear if all proteins with PARP signatures actually function as enzymes. For example, while TCDD-inducible PARP, PARP-9, and PARP-10 have replaced an important catalytic residue (Glu) with nonconserved residues (Aguiar et al, 2000;Ma et al, 2001;Yu et al, 2005), PARP-9 is enzymatically inactive (Aguiar et al, 2005), while TCDD-inducible PARP is enzymatically active (Ma et al, 2001) and PARP-10 has transferase activity rather than polymerase activity, adding one ADP-Rib subunit to target proteins (Yu et al, 2005;Chou et al, 2006;Kleine et al, 2008).…”

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confidence: 99%

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

2009

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RADICAL-INDUCED CELL DEATH1 (RCD1) and SIMILAR TO RCD ONE1 (SRO1) are the only two proteins encoded in the Arabidopsis (Arabidopsis thaliana) genome containing both a putative poly(ADP-ribose) polymerase catalytic domain and a WWE protein-protein interaction domain, although similar proteins have been found in other eukaryotes. Poly(ADP-ribose) polymerases mediate the attachment of ADP-ribose units from donor NAD + molecules to target proteins and have been implicated in a number of processes, including DNA repair, apoptosis, transcription, and chromatin remodeling. We have isolated mutants in both RCD1 and SRO1, rcd1-3 and sro1-1, respectively. rcd1-3 plants display phenotypic defects as reported for previously isolated alleles, most notably reduced stature. In addition, rcd1-3 mutants display a number of additional developmental defects in root architecture and maintenance of reproductive development. While single mutant sro1-1 plants are relatively normal, loss of a single dose of SRO1 in the rcd1-3 background increases the severity of several developmental defects, implying that these genes do share some functions. However, rcd1-3 and sro1-1 mutants behave differently in several developmental events and abiotic stress responses, suggesting that they also have distinct functions. Remarkably, rcd1-3; sro1-1 double mutants display severe defects in embryogenesis and postembryonic development. This study shows that RCD1 and SRO1 are at least partially redundant and that they are essential genes for plant development.

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confidence: 99%

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

2009

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“…Indeed, several members of the sirtuin family of NAD ϩ -dependent histone deacetylases (SIRTs) were found to posses mono-ADP-ribosyltransferase activities and thus could represent a putative novel family of intracellular MARTs (128,132,234,391). Moreover, very recent reports described 11 additional novel mammalian Parplike genes (5,20,140) that may be good candidates to be members of a putative large family of intracellular PARP-like MARTs (5,6,241,309,452; reviewed in references 20 and 140). Although clear biochemical evidence for protein-mono-ADP-ribosylation by the SIRTs and PARP-like ADP-ribosyltransferases has yet to be established (309,371), growing families of MARTs and PARPs exist and may be responsible for distinct mono-ADP-ribosylation and poly-ADP-ribosylation reactions in mammalian cells (20,140,161,309).…”

Section: Historical Overviewmentioning

confidence: 99%

“…During the last 10 years, more than 16 novel Parp-like genes were cloned or described based on thorough searches of nonredundant databases (5,6,20,130,140,241,309,452). Among all 17 human and 16 mouse Parp-like genes, only the 6 human and mouse "bona fide" poly-ADP-ribose polymerase gene products contain an evolutionarily conserved catalytic glutamate residue (309).…”

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confidence: 99%

Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

Hassa

Haenni

Elser

et al. 2006

Microbiol Mol Biol Rev

635

644

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SUMMARY Since poly-ADP ribose was discovered over 40 years ago, there has been significant progress in research into the biology of mono- and poly-ADP-ribosylation reactions. During the last decade, it became clear that ADP-ribosylation reactions play important roles in a wide range of physiological and pathophysiological processes, including inter- and intracellular signaling, transcriptional regulation, DNA repair pathways and maintenance of genomic stability, telomere dynamics, cell differentiation and proliferation, and necrosis and apoptosis. ADP-ribosylation reactions are phylogenetically ancient and can be classified into four major groups: mono-ADP-ribosylation, poly-ADP-ribosylation, ADP-ribose cyclization, and formation of O-acetyl-ADP-ribose. In the human genome, more than 30 different genes coding for enzymes associated with distinct ADP-ribosylation activities have been identified. This review highlights the recent advances in the rapidly growing field of nuclear mono-ADP-ribosylation and poly-ADP-ribosylation reactions and the distinct ADP-ribosylating enzyme families involved in these processes, including the proposed family of novel poly-ADP-ribose polymerase-like mono-ADP-ribose transferases and the potential mono-ADP-ribosylation activities of the sirtuin family of NAD+-dependent histone deacetylases. A special focus is placed on the known roles of distinct mono- and poly-ADP-ribosylation reactions in physiological processes, such as mitosis, cellular differentiation and proliferation, telomere dynamics, and aging, as well as “programmed necrosis” (i.e., high-mobility-group protein B1 release) and apoptosis (i.e., apoptosis-inducing factor shuttling). The proposed molecular mechanisms involved in these processes, such as signaling, chromatin modification (i.e., “histone code”), and remodeling of chromatin structure (i.e., DNA damage response, transcriptional regulation, and insulator function), are described. A potential cross talk between nuclear ADP-ribosylation processes and other NAD+-dependent pathways is discussed.

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“…(27) TiPARP (PARP-7) was identified by differential display as a 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced mRNA. (34) The exact function of TiPARP remains unclear. It seems to be involved in T-cell function, and its induction by TCDD contributes to tumor promotion.…”

Section: The Parp Superfamily: Seven Isolated Cdnasmentioning

confidence: 99%

The PARP superfamily

2004

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SummaryPoly(ADP-ribosyl)ation is an immediate DNA-damagedependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this posttranslational modification of proteins. This review summarizes our present knowledge of this emerging superfamily, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders. A provisional nomenclature is proposed.

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TCDD-Inducible Poly(ADP-ribose) Polymerase: A Novel Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Cited by 129 publications

References 38 publications

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

The PARP superfamily

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