tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol, affects neural stem fate and differentiation by modulating Notch1 activity

The Immune System as Drug Target

“…This can be at the level of whole cells, such as professional antigen presenting cells, B-cells or T-cells, or at the level of whole organs, from lymph nodes upwards. Perhaps the clearest example of this is the idea of using drugs to direct stems to differentiate within the immune environment, as has been done in other areas, [23][24][25] and the potential of unwanted immunogenicity of stem cell therapeutics. 26,27 Hand-in-hand with the idea of the immune system as a hierarchy of targets is the concept of polypharmacy directed at many immune targets.…”