TCM monotherapy achieves significant efficacy in crizotinib-refractory advanced NSCLC with brain metastasis

Abstract

Rationale: The morbidity and mortality of lung cancer rank the first among all kinds of cancer. In China, anaplastic lymphoma kinase-positive pulmonary tumors account for nearly 5% of non-small cell lung cancer (NSCLC), and these patients are quite likely to develop brain metastases, as high as around 45%. Although anaplastic lymphoma kinase-tyrosine kinase inhibitors crizotinib and alectinib have proved effective for controlling tumor metastases to the brain, drug resistance and disease progression cannot be ignored in the course of treatment. Patient concerns: Most of the literature reports that traditional Chinese medicine (TCM) has produced satisfactory results in the treatment of cancer patients as an adjuvant treatment for various malignancies in a 53-year-old male patient who developed advanced NSCLC with brain metastases. As first-line crizotinib and erlotinib treatments were ineffective and the intracranial lesions progressed extensively, the patient chose to receive TCM treatment alone in the hope of prolonging his life and improving his quality of life. Diagnoses: A 53-year-old male patient who developed advanced NSCLC with brain metastasis. Because first-line crizotinib and alectinib have failed, and the intracranial lesions progressed in a large area. Interventions: The patient requested that the final therapeutic strategy be Chinese medicine as monotherapy for long-term treatment. The patient took 30 mL of the decoction 1 hour after a meal, 3 times a day. The patient was not treated with dehydrating agents or diuretics during the TCM treatment. Outcomes: The improvement was obvious after 3 months of treatment, and significant reduction of cranial lesions. During the follow-up period, the patient developed neither severe liver damage nor kidney damage. Lessons: This case is the first 1 in the world where TCM was introduced as monotherapy for severe conditions with extensive brain metastases and achieved remarkable efficacy.

The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy

“…Many metabolites of TCM have been used for prophylaxis and therapeutics of cancers with unique advantages ( Xiang et al, 2019 ). These metabolites reverse cancer multidrug resistance, reduce postoperative adverse reactions, improve patients’ quality of life, and potentiate anti-PD-1/PD-L1 immunotherapy ( Huang F. et al, 2022 ; Wei et al, 2022 ; Qin et al, 2023 ). However, the exact targets and signal pathways of most TCM drugs used in the treatment process are not fully elucidated.…”