TCT-444 Efficacy of Anterograde Interventional Gene Delivery with Different AAV Serotypes in a Pre-Clinical Large Animal Model

Abstract

and BVS (p< 0.05) (Figure). The number of platelet aggregation clots was the least in Synergy DES with a borderline significant difference compared to other stents. Conclusions:The current ex vivo swine shunt model demonstrated decreased acute thrombogenicity in bioerodible polymer thin-strut Synergy as compared to bioerodible thick-strut Biomatrix Flex and fully bioresorbable Absorb, which confirms the acute protective function of bioerodible stent coatings and emphasizes the relevance of stent geometry in acute thrombogenicity.