TCT-738 The Degree of Right-to-Left Shunt is Associated with Visual Aura Due to Migraine

Kijima, Yasufumi; Miller, Nicholas; Noureddin, Nabil; Gevorgyan, Rubine; Tobis, Jonathan M.

doi:10.1016/j.jacc.2015.08.761

Cited by 4 publications

(3 citation statements)

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“…Thus, it is plausible that RLS's influence extends to the inferior temporal gyrus, rendering migraine patients with RLS more susceptible to visual aura. This aligns with prior research by Kijima Y et al, wherein they reported higher RLS grades in the migraine group with frequent visual aura compared to those with episodic visual aura or no visual aura (Kijima Y et al, 2015). Consequently, our study further supports the association between RLS and migraine, viewed through the lens of brain function.…”

Section: Difference In Small-world Properties and Nodal Propertiessupporting

confidence: 93%

Right-to-Left Shunt-associated Brain Functional Changes in Migraine: Evidences from a Resting-state FMRI Study

Cao,

Jiao,

Zhou

et al. 2024

Preprint

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Background: Migraine, a neurological disorder under perpetual investigation, has an elusive etiology. An potential association with Right-to-Left Shunt (RLS) exists, yet the precise nature of this connection remains unclear.This study employs the resting-state functional magnetic resonance imaging (rs-fMRI) technique to examine brain functional differences between the migraine patients with and without RLS, aiming at exploring RLS associated alterations in functional segregation and integration. Methods: This study included 32 migraine patients (14 patients with RLS and 18 without RLS), each undergoing rs-fMRI data acquisition. The amplitude of low-frequency fluctuation (ALFF) was employed to investigate functional segregation. Functional connectivity (FC) analysis was conducted to explore the functional integration across distinct brain regions. Graph theory-based network analysis was utilized to assess functional networks in migraine patients with RLS. Pearson correlation analysis further explored the relationship between RLS severity and various functional metrics.. Results: Compared with migraine patients without RLS, migraine patients with RLS exhibited a significant increase in the ALFF in the left middle occipital and superior occipital gyrus; As to FC, the reduced connectivity between the left rolandic operculum and the right middle cingulate gyrus was observed in migraine patients with RLS; Based on the brain networks analysis, migraine patients with RLS displayed higher values of the normalized clustering coefficient and greater betweenness centrality in specific regions, including the left precuneus, right insula, and right inferior temporal gyrus. Further, the study found positive correlations between ALFF values in the temporal lobes, thalamus, left middle occipital, and superior occipital gyrus and RLS severity. Conversely, negative correlations emerged between ALFF values in the right inferior frontal gyrus, middle frontal gyrus, and insula and RLS grading. Finally, the study identified a positive correlation between angular gyrus betweenness centrality and RLS severity. Conclusion: RLS-associated brain functional alterations in migraine consisted of local brain regions, connectivity, and networks involved in pain conduction and regulation did exist in migraine with RLS.

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Section: Difference In Small-world Properties and Nodal Propertiessupporting

confidence: 93%

Right-to-Left Shunt-associated Brain Functional Changes in Migraine: Evidences from a Resting-state FMRI Study

Cao,

Jiao,

Zhou

et al. 2024

Preprint

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“…A large number of observational studies have shown that the prevalence of PFO in people with migraine aura is higher than that in the general population [ 19 ]. Interestingly, in 2015, Kijima et al found that there was a positive correlation between the flow of PFO and the frequency of visual aura [ 20 ]. Furthermore, the presence of RLS is related to the onset age of migraine with aura [ 21 ].…”

Section: Pfo and Migrainementioning

confidence: 99%

The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence

et al. 2022

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Migraine is a common neurological disease with a still-unclear etiology and pathogenesis. Patent foramen ovale (PFO) is a kind of congenital heart disease that leads to a right-to-left shunt (RLS). Although previous studies have shown that PFO has an effect on migraine, a clear conclusion about the link between PFO and migraine is lacking. We first summarized the PFO potential mechanisms associated with migraine, including microembolus-triggered cortical spreading depression (CSD), the vasoactive substance hypothesis, impaired cerebral autoregulation (CA), and a common genetic basis. Further, we analyzed the changes in brain structure and function in migraine patients and migraine patients with PFO. We found that in migraine patients with PFO, the presence of PFO may affect the structure of the cerebral cortex and the integrity of white matter, which is mainly locked in subcortical, deep white matter, and posterior circulation, and may lead to changes in brain function, such as cerebellum and colliculus, which are involved in the processing and transmission of pain. In summary, this paper provides neuroimaging evidence and new insights into the correlation between PFO and migraine, which will help to clarify the etiology and pathogenesis of migraine, and aid in the diagnosis and treatment of migraine in the future.

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“…A hundred and forty two migraine patients were divided into (i) frequent aura group (number of visual aura >50% of frequency of headaches) and (ii) accidental aura group (number of visual aura <50% of frequency of headaches). The results showed that migraine patients with frequent visual aura suffered a higher degree of RLS, and the symptoms improved after PFO closure ( 37 ). The high prevalence of PFO in chronic migraine patients do not indicate that PFO tend to stimulate chronic headaches, but still is associated with the number of migraine attacks, especially for large, high grade shunts.…”

Section: The Relationship Between Migraine and Patent Foramen Ovalementioning

confidence: 99%

The Correlation Between Migraine and Patent Foramen Ovale

Liu

Wang

et al. 2020

Front. Neurol.

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Background: Migraine is a widespread neurological disorder. The patent foramen ovale (PFO) is a remnant of the fetal circulation. Multiple studies suggest that migraine is more prevalent in subjects with PFO and vice versa. It is unclear if there is a causal relationship or simply a co-existence of these two conditions. Furthermore, the treatment of migraine with percutaneous closure PFO remains controversial.Methods: We reviewed studies pertaining to the relationship between PFO and migraine as well as the effects of treatments on migraine attacks.Results: We briefly summarized potential pathophysiological mechanisms of migraine, and elaborated on migraine type, frequency, and clinical symptoms of migraine with PFO and the clinical features of PFO with migraine. We also addressed the effects of PFO closure on migraine attacks.Conclusion: The evidence supports a “dose-response” relationship between migraine and PFO although more work needs to be done in terms of patient selection as well as the inclusion of an antiplatelet control group for PFO closure interventions to uncover possible beneficial results in clinical trials.

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TCT-738 The Degree of Right-to-Left Shunt is Associated with Visual Aura Due to Migraine

Cited by 4 publications

References 0 publications

Right-to-Left Shunt-associated Brain Functional Changes in Migraine: Evidences from a Resting-state FMRI Study

Right-to-Left Shunt-associated Brain Functional Changes in Migraine: Evidences from a Resting-state FMRI Study

The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence

The Correlation Between Migraine and Patent Foramen Ovale

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