tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators

Lopes, Bettega Costa; Medeiros, Liciane Fernandes; Stein, Dirson João; Cioato, Stefânia Giotti; Souza, Vanessa Silva de; Medeiros, Helouise Richardt; Sanches, Paulo Roberto Stefani; Fregni, Felipe; Caumo, Wolnei; Torres, Iraci Lucena da Silva

doi:10.1016/j.bbr.2021.113173

Cited by 15 publications

(9 citation statements)

References 69 publications

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“…Adrenocorticotropic hormone and cortisol levels are the opposite case, which only increased after the parachutes' jump in blood. These finding matches with the other data, that NGF level is increased with the drug withdrawal in drug-addicted persons, which suggests that there is a correlation between drug addiction and withdrawal distress [61]. Additional conditions characterizing anxiety in humans such as quitting smoking or caring for a seriously ill wife, both are stressful conditions associated with anxiety and an increased level of NGF in the blood is observed in these conditions [62].…”

Section: Elevated Level Of Ngf In Humans During Anxietysupporting

confidence: 88%

Venom Derived Nerve Growth Factors and Their Potential Therapeutic Applications

Ullah¹

2022

AJBSR

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Venom is a natural source of therapeutically active compounds, exhibiting pharmacological action. Nerve growth factors represent a group of proteins responsible for the upkeep and separation of thoughtful and tangible neurons of the fringe sensory system of vertebrates. Many arthropods have been the moderate source of nerve growth factors with contradictory outcomes. Many studies report many diverse nerve growth factors, which are therapeutically and biologically active but differ widely in their isoelectric properties, immunological cross-reactivity with antibodies to mouse b-NGF, endogenous levels of ester peptidase activity as well as molecular weight.

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Section: Elevated Level Of Ngf In Humans During Anxietysupporting

confidence: 88%

Venom Derived Nerve Growth Factors and Their Potential Therapeutic Applications

Ullah¹

2022

AJBSR

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Section: Introductionmentioning

confidence: 99%

“…Anxiety and mood disorders are more prevalent among patients with CPP (Bruckenthal, 2011; Delanerolle et al, 2021; Dunbar et al, 2021; Lopes et al, 2021; Siqueira‐Campos et al, 2019). They represent key causes of distress, altered functioning and poor quality of life (Dunbar et al, 2021; Lopes et al, 2021; Siqueira‐Campos et al, 2019). Multiple overlapping mechanisms such as alterations in neurotrophins and inflammatory mediators operate simultaneously to drive pain, anxiety and depression (Arango‐Dávila & Rincón‐Hoyos, 2018; Consonni et al, 2021; Dunbar et al, 2021; Lopes et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…They represent key causes of distress, altered functioning and poor quality of life (Dunbar et al, 2021; Lopes et al, 2021; Siqueira‐Campos et al, 2019). Multiple overlapping mechanisms such as alterations in neurotrophins and inflammatory mediators operate simultaneously to drive pain, anxiety and depression (Arango‐Dávila & Rincón‐Hoyos, 2018; Consonni et al, 2021; Dunbar et al, 2021; Lopes et al, 2021). CPP in many instances is difficult‐to‐treat, rendering patients at risk for psychological frailty.…”

Section: Introductionmentioning

confidence: 99%

“…CPP in many instances is difficult‐to‐treat, rendering patients at risk for psychological frailty. Painful manifestations may contribute to mood dysfunction, especially when pain is persistent rather than intermittent (Arango‐Dávila & Rincón‐Hoyos, 2018; Consonni et al, 2021; Dunbar et al, 2021; Lopes et al, 2021). In addition, CPP may exacerbate depressive mood by promoting constant patterns of cognitive biases (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Cut‐off scores of the Depression Anxiety Stress Scale‐8: Implications for improving the management of chronic pain

Ali,

Alameri,

Brooks

et al. 2023

Journal of Clinical Nursing

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AimMental distress, non‐specific symptoms of depression and anxiety, is common in chronic pelvic pain (CPP). It contributes to poor recovery. Women's health nurses operate in multidisciplinary teams to facilitate the assessment and treatment of CPP. However, valid cut‐off points for identifying highly distressed patients are lacking, entailing a gap in CPP management.DesignThis instrumental cross‐sectional study identified a statistically derived cut‐off score for the Depression Anxiety Stress Scale‐8 (DASS‐8) among 214 Australian women with CPP (mean age = 33.3, SD = 12.4, range = 13–71 years).MethodsReceiver operator characteristic curve, decision trees and K‐means clustering techniques were used to examine the predictive capacity of the DASS‐8 for psychiatric comorbidity, pain severity, any medication intake, analgesic intake and sexual abuse. The study is prepared according to the STROBE checklist.ResultsCut‐off points resulting from the analysis were ordered ascendingly. The median (13.0) was chosen as an optimal cut‐off score for predicting key outcomes. Women with DASS‐8 scores below 15.5 had higher analgesic intake.ConclusionCPP women with a DASS‐8 score above 13.0 express greater pain severity, psychiatric comorbidity and polypharmacy. Thus, they may be a specific target for nursing interventions dedicated to alleviating pain through the management of associated co‐morbidities.Implications for patient careAt a cut‐off point of 13.0, the DASS‐8 may be a practical instrument for recommending a thorough clinician‐based examination for psychiatric comorbidity to facilitate adequate CPP management. It may be useful for evaluating patients' response to nursing pain management efforts. Replications of the study in different populations/countries are warranted.

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Role of Exercise on Inflammation Cytokines of Neuropathic Pain in Animal Models

Zheng,

Wang

et al. 2024

Mol Neurobiol

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tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators

Cited by 15 publications

References 69 publications

Venom Derived Nerve Growth Factors and Their Potential Therapeutic Applications

Venom Derived Nerve Growth Factors and Their Potential Therapeutic Applications

Cut‐off scores of the Depression Anxiety Stress Scale‐8: Implications for improving the management of chronic pain

Role of Exercise on Inflammation Cytokines of Neuropathic Pain in Animal Models

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