tDCS in post-stroke aphasia: The role of stimulation parameters, behavioral treatment and patient characteristics

Aguiar, Vânia de; Paolazzi, Caterina Laura; Miceli, Gabriele

doi:10.1016/j.cortex.2014.08.015

Cited by 94 publications

(97 citation statements)

References 106 publications

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“…As it is often difficult to predict the modulatory effects from these techniques ( i.e. , whether enhancing or suppressing the activity)[18,19], it is important to note that the fundamental neural mechanisms underpinning the efficacy of these techniques are still unknown, and a significant amount of work remains in determining their efficacy and method of deployment. With further studies on pulsing parameters to manipulate regional brain activity, the potential use of low-intensity FUS may be broadened to clinical application and brain mapping research.…”

Section: Discussionmentioning

confidence: 99%

Suppression of EEG visual-evoked potentials in rats through neuromodulatory focused ultrasound

et al. 2015

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We investigated the use of pulsed low-intensity focused ultrasound (FUS) to suppress the visual neural response induced by light stimulation in rodents. FUS was administered transcranially to the rat visual cortex using different acoustic intensities and pulsing duty cycles. The visual evoked potentials (VEP) generated by an external strobe light stimulation were measured three times before, once during, and five times after the sonication. The VEP magnitude was suppressed during the sonication using a 5% duty cycle (pulse-repetition frequency of 100 Hz) and spatial-peak pulse-average acoustic intensity of 3 W/cm2; however, this suppressive effect was not present when a lower acoustic intensity and duty cycle were used. The application of a higher intensity and duty cycle resulted in a slight elevation of VEP magnitude, which suggested excitatory neuromodulation. Our findings demonstrate that the application of pulsed FUS to the region-specific brain area not only suppresses its excitability, but also can enhance the excitability depending on the acoustic intensity and rate of energy deposition. This bimodal feature of FUS-mediated neuromodulation, which has been predicted by numerical models on neural membrane capacitance change by the external acoustic pressure waves, suggests its versatility for neurotherapeutic applications.

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Section: Discussionmentioning

confidence: 99%

Suppression of EEG visual-evoked potentials in rats through neuromodulatory focused ultrasound

et al. 2015

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“…is too wide, given the cost and risk of human trials, for "blind" empirical optimization. Computational neurostimulation is thus necessary for rational optimization of neuromodulation protocols (Beriault et al, 2012;de Aguiar et al, 2015). At early stages, such effort must be highly experimental data constrained (Douglas et al, 2015;Merlet et al, 2013;Shamir et al, 2015) and typically constrained to a limited range of dose settings.…”

Section: Dealing With Unknowns and Multiscale Approachesmentioning

confidence: 99%

Modeling sequence and quasi-uniform assumption in computational neurostimulation

Bikson¹,

Truong²,

Mourdoukoutas³

et al. 2015

Progress in Brain Research

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“…The influence of the anatomical extension and localisation of the left hemisphere lesion upon the participation of the RH to the recovery of language According to most authors (e.g., Anglade et al, 2014;Ansaldo, Arguin, & Roch Lecours, 2002;Crosson et al 2007;Hillis, 2007;Schlaug, Marchina & Wand, 2011;Gold & Kertesz, 2000;Heiss et al, 1993;Karbe et al, 1998;Rosen et al, 2000), the two main paths to recovery differ according to the anatomical extension of the LH lesion. In patients with small LH lesions, the recruitment of left perilesional areas with minor involvement of RH structures tends to be prominent.…”

Section: Introductionmentioning

confidence: 97%

Contrasting opinions on the role of the right hemisphere in the recovery of language. A critical survey

Gainotti

2015

Aphasiology

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Background: The role of the right hemisphere (RH) in the recovery of language is quite controversial. Aims: The aim of the present survey consisted in taking into account three main models advanced to explain the reconstitution of language systems: (1) the "perilesional hypothesis," which maintains that language recovery is mainly subsumed by left hemisphere (LH) tissue adjacent to the lesion; (2) the "right hemisphere hypothesis," which assumes that restitution of language entails an increased participation of the RH; and (3) the "disinhibition hypothesis," which maintains that recovery is facilitated by disruption of inhibitions exerted by RH regions over LH language areas. Methods & Procedures: The prognostic factors in poststroke aphasia are discussed first, focusing attention on factors that could subsume an increased participation of the RH to the recovery of language. Then results obtained with techniques of noninvasive brain stimulations of the RH are taken critically into account. Outcomes & Results: As for the prognostic factors, the following points are stressed:(1) the anatomical extension of the LH lesion plays an important role both on the degree and on the path of recovery; (2) the RH structures involved in the recovery of language are generally mirror structures of the damaged LH areas; and (3) the time elapsed since the onset of aphasia influences the contribution that contralateral and ipsilesional areas give to the recovery of language. As for results obtained with techniques of noninvasive brain stimulations of the RH, this point remains controversial, because most authors support the "disinhibition hypothesis," but theoretical and factual reasons suggest caution in the interpretation of these results. Conclusions: Since the meaning of the RH activations and of results obtained with techniques of noninvasive brain stimulations remain controversial, some tentative recommendations to clarify these issues are advanced.

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tDCS in post-stroke aphasia: The role of stimulation parameters, behavioral treatment and patient characteristics

Cited by 94 publications

References 106 publications

Suppression of EEG visual-evoked potentials in rats through neuromodulatory focused ultrasound

Suppression of EEG visual-evoked potentials in rats through neuromodulatory focused ultrasound

Modeling sequence and quasi-uniform assumption in computational neurostimulation

Contrasting opinions on the role of the right hemisphere in the recovery of language. A critical survey

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