TDCS over the right inferior frontal gyrus disrupts control of interference in memory: A retrieval-induced forgetting study

Stramaccia, Davide Francesco; Penolazzi, Barbara; Altoè, Gianmarco; Galfano, Giovanni

doi:10.1016/j.nlm.2017.07.005

Cited by 39 publications

(19 citation statements)

References 72 publications

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“…The evidence also suggested that tDCS did not affect P3 latency measures or prEMG latencies. While our behavioral results contrast with some previous reports of SSRT reductions following anodal IFG stimulation [30][31][32][33][34][35][36] , they are in line with other studies failing to find any SSRT modulations 10,43 . This discrepancy could be driven by several methodological differences between this and earlier reports, such as experimental design, electrode locations, or stimulation lateralization.…”

Section: Discussionsupporting

confidence: 63%

tDCS over the inferior frontal gyri and visual cortices did not improve response inhibition

Thunberg

Messel

Raud

et al. 2020

Sci Rep

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The ability to cancel an already initiated response is central to flexible behavior. While several different behavioral and neural markers have been suggested to quantify the latency of the stopping process, it remains unclear if they quantify the stopping process itself, or other supporting mechanisms such as visual and/or attentional processing. the present study sought to investigate the contributions of inhibitory and sensory processes to stopping latency markers by combining transcranial direct current stimulation (tDcS), electroencephalography (eeG) and electromyography (eMG) recordings in a withinparticipant design. Active and sham tDcS were applied over the inferior frontal gyri (ifG) and visual cortices (VC), combined with both online and offline EEG and EMG recordings. We found evidence that neither of the active tDCS condition affected stopping latencies relative to sham stimulation. Our results challenge previous findings suggesting that anodal tDCS over the IFG can reduce stopping latency and demonstrates the necessity of adequate control conditions in tDcS research. Additionally, while the different putative markers of stopping latency showed generally positive correlations with each other, they also showed substantial variation in the estimated latency of inhibition, making it unlikely that they all capture the same construct exclusively.

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Section: Discussionsupporting

confidence: 63%

tDCS over the inferior frontal gyri and visual cortices did not improve response inhibition

Thunberg

Messel

Raud

et al. 2020

Sci Rep

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“…While Cunillera et al (2014) reported a simultaneous modulation of two kinds of inhibition processes (reactive and proactive inhibition processes), by a-tDCS on the right IFG, using SST and GNGT, respectively. Additionally, Stramaccia et al (2017) revealed that tDCS over the right IFG disrupts control over interference using memory inhibition tasks. Therefore, one should take into consideration the type of task used to measure IC.…”

Section: Discussionmentioning

confidence: 99%

“…tDCS is a non-invasive tool that modulates brain function through hyper-or hypopolarization of neurons (Stagg and Nitsche 2011;Medeiros et al 2012). Stramaccia and coauthors reported evidence about the role of the right IFG in inhibition accuracy in SST (Stramaccia et al 2015) and, in interference control during memory retrieval processes (Stramaccia et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of transcranial direct current stimulation of left and right inferior frontal gyrus on creative divergent thinking are moderated by changes in inhibition control

et al. 2020

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Divergent thinking (DT) as one component of creativity is the ability to search for multiple solutions to a single problem and is reliably tested with the Alternative Uses Task (AUT). DT depends on activity in the inferior frontal gyrus (IFG), a prefrontal region that has also been associated with inhibitory control (IC). Experimentally manipulating IC through transcranial direct current stimulation (tDCS) led to alterations in DT. Here, we aimed at further examining such potential mediating effects of IC on DT (measured as flexibility, fluency, and originality in the AUT) by modulating IC tDCS. Participants received either cathodal tDCS (c-tDCS) of the left IFG coupled with anodal tDCS (a-tDCS) of the right IFG (L−R + ; N = 19), or the opposite treatment (L + R−; N = 21). We hypothesized that L + R− stimulation would enhance IC assessed with the Go NoGo task (GNGT), and that facilitated IC would result in lower creativity scores. The reversed stimulation arrangement (i.e., L− R +) should result in higher creativity scores. We found that tDCS only affected the originality component of the AUT but not flexibility or fluency. We also found no effects on IC, and thus, the mediation effect of IC could not be confirmed. However, we observed a moderation effect: inhibition of left and facilitation of right IFG (L−R +) resulted in enhanced flexibility and originality scores, only when IC performance was also improved. We conclude that inducing a right-to-left gradient in IFG activity by tDCS is efficient in enhancing DT, but only under conditions where tDCS is sufficient to alter IC performance as well. Keywords Creativity • Divergent thinking (DT) • AUT (alternative uses task) • Fluency • Originality • Flexibility • tDCS • IFG Abbreviations AP Action potentials AUT Alternative uses task DT Divergent thinking EFs Executive functions GNGT Go No Go task IC Inhibitory control IFG Inferior frontal gyrus PFC Prefrontal cortex rDLPFC Right dorsolateral prefrontal cortex tDCS Transcranial direct current stimulation Electronic supplementary material The online version of this article (

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“…Similarly, no effect of cathodal stimulation on SST performance was reported by studies using offline tDCS over the right inferior frontal gyrus (or, most recently, Stramaccia et al, 2015). Interestingly, in a study utilizing online tDCS, neither anodal nor cathodal stimulation affected SSRT (Stramaccia, Penolazzi, Altoè, & Galfano, 2017). Furthermore, some studies investigated the effects of cathodal stimulation on tasks similar to the SST, such as an anticipation timing task with a motor component (Hayduk-Costa, Drummond, & Carlsen, 2013), a cognitive reflection task (Oldrati, Patricelli, Colombo, & Antonietti, 2016), or a go/no-go task (Lapenta, Fregni, Oberman, & Boggio, 2012).…”

Section: Cathodal Tdcs and Its Effects On Response Inhibitionmentioning

confidence: 90%

Cathodal tDCS increases stop-signal reaction time

Friehs

Frings

2019

Cogn Affect Behav Neurosci

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Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating human brain activity and potentially alters performance in cognitive tasks. Often it is assumed that effects of tDCS modulation depend on the polarity-anodal stimulation typically boost cognitive processes whereas cathodal stimulation hampers them. While most tDCS research focusses on the effects of anodal stimulation, cathodal tDCS effects are underexplored. In the present study, cathodal tDCS over the right dorsolateral prefrontal cortex (rDLPFC) was used to potentially hamper the response inhibition process as measured by the stop-signal task (SST). A 9 cm 2 cathode was always positioned over the rDLPFC while the 35 cm 2 anode was placed over the left deltoid. We contrasted a cathodal stimulation condition (that is assumed to reduce neural processing) with sham stimulation and expected a decrease in SST performance after cathodal tDCS, as evidenced by an increase in stop-signal reaction time (SSRT). In a sample of N = 45 healthy adults, a significant Time × tDCS condition interaction emerged, indicating an increase in SSRT after cathodal tDCS. In a recent study by Friehs and Frings (Journal of Experimental Psychology: Human Perception and Performance, 2018), using a similar study design and stimulation protocol, single-session anodal tDCS over the rDLPFC was used to enhance SST performance as indicated by an acceleration of SSRT. In concert, these results suggest that response inhibition is tied to the neural state of the rDLPFC.

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TDCS over the right inferior frontal gyrus disrupts control of interference in memory: A retrieval-induced forgetting study

Cited by 39 publications

References 72 publications

tDCS over the inferior frontal gyri and visual cortices did not improve response inhibition

tDCS over the inferior frontal gyri and visual cortices did not improve response inhibition

Effects of transcranial direct current stimulation of left and right inferior frontal gyrus on creative divergent thinking are moderated by changes in inhibition control

Cathodal tDCS increases stop-signal reaction time

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