Te–Cefotaxime nanocomposites with restored antibiotic susceptibility and the LED light activated photothermal effect for rapid MRSA eradication

Wu, Shaochuan; Liu, Xiangyu; Zhao, Li; Lu, Zhong; Jiang, Nan; Yang, Hao; Yao, Huaiying

doi:10.1039/d1tb02538d

Cited by 4 publications

(1 citation statement)

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“…Based on the great photothermal properties of tellurium NPs, the combination of tellurium NPs and PTT has gradually become a new popular trend. Wu et al (2022) used cefotaxime (CTX)-loaded tellurium nanoparticles (Te-CTX NPs) as a photothermal agent, which, when irradiated by laser, produced a combined antibacterial effect of two synergistic pathways of PTT and CTX. On the one hand, Te restores the sensitivity of CTX to MRSA; on the other hand, the high temperature effect induced by PTT can destroy the antioxidant defense system of bacteria (Figure 5E).…”

Section: Telluriummentioning

confidence: 99%

Inorganic nanomaterials for intelligent photothermal antibacterial applications

Wang

Shao

et al. 2022

Front. Bioeng. Biotechnol.

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Antibiotics are currently the main therapeutic agent for bacterial infections, but they have led to bacterial resistance, which has become a worldwide problem that needs to be addressed. The emergence of inorganic nanomaterials provides a new opportunity for the prevention and treatment of bacterial infection. With the continuous development of nanoscience, more and more inorganic nanomaterials have been used to treat bacterial infections. However, single inorganic nanoparticles (NPs) are often faced with problems such as large dosage, strong toxic and side effects, poor therapeutic effect and so on, so the combination of inorganic nano-materials and photothermal therapy (PTT) has become a promising treatment. PTT effectively avoids the problem of bacterial drug resistance, and can also reduce the dosage of inorganic nanomaterials to a certain extent, greatly improving the antibacterial effect. In this paper, we summarize several common synthesis methods of inorganic nanomaterials, and discuss the advantages and disadvantages of several typical inorganic nanomaterials which can be used in photothermal treatment of bacterial infection, such as precious metal-based nanomaterials, metal-based nanomaterials and carbon-based nanomaterials. In addition, we also analyze the future development trend of the remaining problems. We hope that these discussions will be helpful to the future research of near-infrared (NIR) photothermal conversion inorganic nanomaterials.

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Section: Telluriummentioning

confidence: 99%