Tea Catechins Suppress Accumulation of Body Fat in Humans

Nagao, Tomonori; Meguro, Shu; Soga, Satoko; Otsuka, Atsuko; Tomonobu, Kazuichi; Fumoto, Shinichi; Chikama, Akiro; Mori, Kensaku; Yuzawa, Masayuki; Watanabe, Hiroyuki; Hase, Tadashi; Tanaka, Yukitaka; Tokimitsu, Ichiro; Shimasaki, Hiroyuki; Itakura, Hiroshige

doi:10.5650/jos.50.717

Cited by 44 publications

(37 citation statements)

References 18 publications

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“…The green tea catechin EGCG has produced positive effects on body mass and composition in animals (Bose et al 2008;Ito et al 2008). Although quercetin had no effect on body mass or composition in the current study, small effects on body mass have been observed with tea catechins (Hase et al 2001;Nagao et al 2001Nagao et al , 2007Harada et al 2005) and other polyphenols such as soy flavonoids (Jenkins et al 2002;Liu et al 2009). However, Park et al (2008) found that a combination of genistein, quercetin, and resveratrol was more effective at inhibiting adipogenesis and inducing apoptosis in human adipocytes than any individual compound alone.…”

Section: Discussionmentioning

confidence: 48%

“…The catechins in green tea may increase thermogenesis and fat oxidation by inhibiting catechol-O-methyltransferase, leading to increased expression of norepinephrine and heightened sympathetic nervous system activity (Borchardt and Huber 1975). Epidemiological research supports the anti-obesity influence of green tea intake (Grove and Lambert 2010), and controlled human trials indicate a small but significant decrease in body mass, waist circumference, and body fat in subjects randomized to green tea extract supplementation (Hase et al 2001;Nagao et al 2001Nagao et al , 2005Nagao et al , 2007. Other polyphenols such as soy isoflavones demonstrate positive effects on weight loss in humans.…”

Section: Introductionmentioning

confidence: 99%

“…The obesity pandemic has accelerated cell, animal, and human research on the anti-obesity effects of flavonoids (Borchardt and Huber 1975;Melzig 1996;Hase et al 2001;Nagao et al 2001Nagao et al , 2005Nagao et al , 2007Singh et al 2003;Alexander 2006;Greenberg et al 2006;Harwood et al 2007;Bose et al 2008;Egert et al 2008;Ito et al 2008;Stewart et al 2008;Liu et al 2009;Faria et al 2010;Grove and Lambert 2010;Zhu et al 2010). For example, several animal studies indicate that 3-15 weeks of supplementation with green tea extract and epigallocatechin gallate (EGCG) reduce body mass and fat mass (Bose et al 2008;Ito et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin with vitamin C and niacin does not affect body mass or composition

Knab

Shanely

Jin

et al. 2011

Appl. Physiol. Nutr. Metab.

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In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45%normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements adminis-tered in double-blind fashion: Q500 = 500 mg quercetin·day-1, Q1000 = 1000 mg quercetin·day-1, and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition meas-urements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and com-position across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a dose-responsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant dif-ferences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, fe-males p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body mass or body composition were found in a subgroup of overweight and obese subjects. High-dose quercetin supplementation (500 and 1000 mg·day-1) for 12 weeks in a large, heterogeneous group of adults did not affect body mass or composition. Abstract: In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 years of age; 45% normal body mass index, 30% overweight, 25% obese). Subjects were randomized into 3 groups, with supplements administered in double-blind fashion: Q500 = 500 mg quercetin·day -1 , Q1000 = 1000 mg quercetin·day -1 , and placebo. Quercetin supplements were consumed twice daily over a 12-week period, and pre-and poststudy body mass and composition measurements were taken in an overnight fasted state. A general linear model was used to predict change in body mass and composition across groups with adjustment for demographic and lifestyle factors. Plasma quercetin increased in a doseresponsive manner in both Q500 and Q1000 groups relative to placebo. After adjustment for confounders, no significant differences in body mass (males interaction p value = 0.721, females p = 0.366) or body composition (males p = 0.650, females p = 0.639) were found between Q500 or Q1000 groups compared with placebo. No group differences in body ma...

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quercetin with vitamin C and niacin does not affect body mass or composition

Knab

Shanely

Jin

et al. 2011

Appl. Physiol. Nutr. Metab.

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show abstract

“…In all but one study, 17 subjects were randomly assigned to two conditions, with seven studies 10,15-20 using a true placebo group and the remaining four studies [11][12][13][14] comparing a high with a low dose of an EGCG-caffeine mixture.…”

Section: Resultsmentioning

confidence: 99%

“…[10][11][12][13][14][15][16][17] On the other hand, studies with Caucasian subjects reported mixed results. [18][19][20] Moreover, the amount of regular caffeine intake may also influence the effectiveness of catechins.…”

Section: Introductionmentioning

confidence: 99%

The effects of green tea on weight loss and weight maintenance: a meta-analysis

2009

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Introduction. Different outcomes of the effect of green tea on weight loss (WL) and weight maintenance (WM) have been reported in studies with subjects differing in ethnicity and habitual caffeine intake. Purpose. To elucidate by meta-analysis whether green tea indeed has a function in body weight regulation. Methods. English-language studies about WL and WM after green tea supplementation were identified through PubMed and based on the references from retrieved articles. Out of the 49 studies initially identified, a total of 11 articles fitted the inclusion criteria and provided useful information for the meta-analysis. Effect sizes (mean weight change in treatment versus control group) were computed and aggregated based on a random-effects model. The influence of several moderators on the effect sizes was examined. Results. Catechins significantly decreased body weight and significantly maintained body weight after a period of WL (m ¼ À1.31 kg; Po0.001). Inhibition of this effect by high habitual caffeine intake (4300 mg per day) failed to reach significance (m ¼ À0.27 kg for high andm ¼ À1.60 kg for low habitual caffeine intake; P ¼ 0.09). Also, the seemingly smaller effect of catechins in Caucasian (m ¼ À0.82 kg) subjects compared with Asians (m ¼ -1.51 kg; P ¼ 0.37) did not reach significance. Interaction of ethnicity and caffeine intake was a significant moderator (P ¼ 0.04). Conclusions. Catechins or an epigallocatechin gallate (EGCG)-caffeine mixture have a small positive effect on WL and WM. The results suggest that habitual caffeine intake and ethnicity may be moderators, as they may influence the effect of catechins.

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Effects of green tea on weight loss and weight maintenance. A meta-analysis

2009

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Tea Catechins Suppress Accumulation of Body Fat in Humans

Cited by 44 publications

References 18 publications

Quercetin with vitamin C and niacin does not affect body mass or composition

Quercetin with vitamin C and niacin does not affect body mass or composition

The effects of green tea on weight loss and weight maintenance: a meta-analysis

Effects of green tea on weight loss and weight maintenance. A meta-analysis

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