Tea combats circadian rhythm disorder syndrome via the gut-liver-brain axis: potential mechanisms speculated

Luo, Liyong; Zeng, Liang

doi:10.1080/10408398.2022.2040945

Cited by 8 publications

(5 citation statements)

References 247 publications

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“…According to Han et al [12] , oat fiber could reverse high-fat diet (HFD)-induced hepatic clock gene disturbances by targeting the circadian rhythm oscillations of gut microbiota and gut microbiota-derived short chain fatty acids (SCFAs). Therefore, the gut-liver axis plays key roles in the maintenance of circadian rhythms and lipid homeostasis, which could be regulated by food-derived bioactive compounds [13][14] .…”

Section: Food Science and Human Wellnessmentioning

confidence: 99%

Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

Zhang¹,

Ho²,

Wei³

et al. 2024

Food Science and Human Wellness

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The interplay between the host circadian clock and microbiota has signifi cant infl uences on host metabolism processes, and circadian desynchrony triggered by high-fat diet (HFD) is closely related to metabolic disorders. In this study, the modulatory effects of piperine (PIP) on lipid metabolism homeostasis, gut microbiota community and circadian rhythm of hepatic clock gene expressions in obese rats were investigated. The Sprague-Dawley (SD) rats were fed with normal diet (ND), HFD and HFD supplemented with PIP, respectively. After 9 weeks, rats were sacrificed with tissue and fecal samples collected for circadian analysis. Results showed that chronic PIP administration ameliorated the obesity-induced alterations in lipid metabolism and dysregulation of hepatic clock gene expressions in obese rats. The gut microbial communities studied through 16S rRNA sequencing showed that PIP ameliorated the imbalanced microbiota and recovered the circadian rhythm of Lactobacillaceae, Desulfovibrionaceae, Paraprevotellaceae, and Lachnospiraceae. The fecal metabolic profi les indicated that 3-dehydroshikimate, cytidine and lithocholyltaurine were altered, which were involved in the amino acid and fatty acid metabolism process. These findings could provide theoretical basis for PIP to work as functional food to alleviate the lipid metabolism disorder, circadian rhythm misalignment, and gut microbiota dysbiosis with wide applications in the food and pharmaceutic industries.

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Section: Food Science and Human Wellnessmentioning

confidence: 99%

Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

Zhang¹,

Ho²,

Wei³

et al. 2024

Food Science and Human Wellness

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“…Exogenous and endogenous amino acids obtained from food in vitro and the breakdown of tissue proteins, respectively, serve as the primary sources of tryptophan in animals (117). Tea contains a small amount of tryptophan, which aids digestion and metabolism, thereby increasing CA levels in plasma (117,118). Earlier investigations indicated that CA possesses anti-inflammatory and antioxidant activity and protects hepatocytes (119, 120).…”

Section: Cinnabarinic Acidmentioning

confidence: 99%

Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis

Tang,

Wang,

Wang

et al. 2023

Front. Endocrinol.

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Obesity occurs when overall energy intake surpasses energy expenditure. White adipose tissue is an energy storage site, whereas brown and beige adipose tissues catabolize stored energy to generate heat, which protects against obesity and obesity-associated metabolic disorders. Metabolites are substrates in metabolic reactions that act as signaling molecules, mediating communication between metabolic sites (i.e., adipose tissue, skeletal muscle, and gut microbiota). Although the effects of metabolites from peripheral organs on adipose tissue have been extensively studied, their role in regulating adipocyte thermogenesis requires further investigation. Skeletal muscles and intestinal microorganisms are important metabolic sites in the body, and their metabolites play an important role in obesity. In this review, we consolidated the latest research on skeletal muscles and gut microbiota-derived metabolites that potentially promote adipocyte thermogenesis. Skeletal muscles can release lactate, kynurenic acid, inosine, and β-aminoisobutyric acid, whereas the gut secretes bile acids, butyrate, succinate, cinnabarinic acid, urolithin A, and asparagine. These metabolites function as signaling molecules by interacting with membrane receptors or controlling intracellular enzyme activity. The mechanisms underlying the reciprocal exchange of metabolites between the adipose tissue and other metabolic organs will be a focal point in future studies on obesity. Furthermore, understanding how metabolites regulate adipocyte thermogenesis will provide a basis for establishing new therapeutic targets for obesity.

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“…The circadian rhythm (CR) of the host and the gut microbes that interfere with each other were suggested to cause various chronic disease problems, such as fatty liver, type 2 diabetes, and chronic gastroenteritis, which affect the metabolism via multi-organ crosstalk (enteric–liver–brain axis etc.) [ 96 , 97 , 98 ]. A recent study found that TFs significantly modulated the circadian clock oscillations of the intestinal flora and the transcription of circadian clock genes induced by continuous dark (CD) treatment in mice [ 99 ].…”

Section: The Interactions Of Theaflavins and Gut Microbiotamentioning

confidence: 99%

Beneficial Effects of Theaflavins on Metabolic Syndrome: From Molecular Evidence to Gut Microbiome

Shi

et al. 2022

IJMS

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In recent years, many natural foods and herbs rich in phytochemicals have been proposed as health supplements for patients with metabolic syndrome (MetS). Theaflavins (TFs) are a polyphenol hydroxyl substance with the structure of diphenol ketone, and they have the potential to prevent and treat a wide range of MetS. However, the stability and bioavailability of TFs are poor. TFs have the marvelous ability to alleviate MetS through antiobesity and lipid-lowering (AMPK-FoxO3A-MnSOD, PPAR, AMPK, PI3K/Akt), hypoglycemic (IRS-1/Akt/GLUT4, Ca2+/CaMKK2-AMPK, SGLT1), and uric-acid-lowering (XO, GLUT9, OAT) effects, and the modulation of the gut microbiota (increasing beneficial gut microbiota such as Akkermansia and Prevotella). This paper summarizes and updates the bioavailability of TFs, and the available signaling pathways and molecular evidence on the functionalities of TFs against metabolic abnormalities in vitro and in vivo, representing a promising opportunity to prevent MetS in the future with the utilization of TFs.

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Tea combats circadian rhythm disorder syndrome via the gut-liver-brain axis: potential mechanisms speculated

Cited by 8 publications

References 247 publications

Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis

Beneficial Effects of Theaflavins on Metabolic Syndrome: From Molecular Evidence to Gut Microbiome

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