Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies

Zhan, Xin; Wang, Jie; Pan, Shufen; Lu, Caijuan

doi:10.18632/oncotarget.16890

Cited by 19 publications

(15 citation statements)

References 44 publications

(44 reference statements)

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“…A pioneering study in the mid-1990s summarized the available epidemiologic information and found that tea consumption is likely to have beneficial effects on reducing the cancer risk in some people [1]. Recently, a meta-analysis found an inverse association between tea consumption and cancer risk [4,58,59,60,61]. However, some evidence does not support the hypothesis that tea can reduce the risk of cancer [62,63].…”

Section: Tea Resists Carcinogenesismentioning

confidence: 99%

“…The functional composition of tea consists of tea polyphenols, tea polysaccharides, L -theanine, tea pigments, caffeine, and tea saponin, some of which are secondary metabolites generated by tea. These active chemicals contribute to the many important properties of tea, such as anti-cancer, anti-aging, anti-microbial, anti-inflammatory, hypoglycemic, and hypotensive activities, along with maintaining health and controlling diseases in human [3,4,5,6,7]. As a major compound, polyphenols are rich in tea (about 30%) and possess anti- or pro-oxidative properties that have been studied widely for more than 30 years.…”

Section: Introductionmentioning

confidence: 99%

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Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism

Mao

Xiao

Chen

et al. 2019

IJMS

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Cancer is a worldwide epidemic and represents a major threat to human health and survival. Reactive oxygen species (ROS) play a dual role in cancer cells, which includes both promoting and inhibiting carcinogenesis. Tea remains one of the most prevalent beverages consumed due in part to its anti- or pro-oxidative properties. The active compounds in tea, particularly tea polyphenols, can directly or indirectly scavenge ROS to reduce oncogenesis and cancerometastasis. Interestingly, the excessive levels of ROS induced by consuming tea could induce programmed cell death (PCD) or non-PCD of cancer cells. On the basis of illustrating the relationship between ROS and cancer, the current review discusses the composition and efficacy of tea including the redox-relative (including anti-oxidative and pro-oxidative activity) mechanisms and their role along with other components in preventing and treating cancer. This information will highlight the basis for the clinical utilization of tea extracts in the prevention or treatment of cancer in the future.

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Section: Tea Resists Carcinogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism

Mao

Xiao

Chen

et al. 2019

IJMS

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“…Two investigators independently assessed the validity of the studies using the Jadad Score [10]. The Jadad score assesses randomisation, blinding, and attrition to derive a score ranging from 0 (low quality) to 5 (high quality).…”

Section: Assessment Of Study Qualitymentioning

confidence: 99%

Anemia and the outcomes in renal transplant recipients: a meta-analysis

Huang¹,

Li²,

Chen³

et al. 2017

Oncotarget

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Background: The impact of anemia on graft loss rate and all-cause death rate remains controversial in renal transplant recipients. We performed a meta-analysis to explore the influence of anemia correction on the outcomes in renal transplant recipients.Materials and Methods: We searched PubMed and EMBASE databases from January 1st 1981 to December 31st, 2016 to identify potential studies assessing the impact of anemia on kidney transplantation. Fixed or random effect model was used according to the heterogeneity. Potential heterogeneity was checked by sensitivity analysis and meta-regression analysis.Results: A total of 9 randomized controlled trials with 1387 participants (mean age ranged from 39 to 53years) were included. Our results showed that anemia correction significantly decreased the creatinine level (WMD 0.52 mg/dl; 95% CI: 0.12, 0.92; P = 0.011), graft loss rate (0.07, 95% CI:0.05, 0.08; P < 0.0001) and allcause death rate (0.01, 95% CI:0.00,0.01; P = 0.023). Furthermore, comparing with control group, erythropoietin (EPO) treatment greatly decreased creatinine level in renal transplant recipients (WMD 1.15 mg/dl; 95% CI: 0.27, 2.03 vs. WMD 0.05 mg/ dl; 95% CI: −0.13, 0.23; P < 0.0001).Conclusions: Our findings showed that anemia correction reduced creatinine level, graft loss rate and all-cause death rate in renal transplant recipients. And EPO treatment is a good choice for anemia correction in renal transplant recipients.

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“…[2] Many natural substances have been identified in green tea; [4] the theanine and catechins components have neuroprotective functions, [5,6] and the catechins inhibit tumor cell proliferation and promote destruction of leukemia cells [7,8] and breast cancer cells. [9] Studies have shown that green tea decreases the risk of ovarian cancer [10] and reduces the proliferation of cervical, [11] prostate [12] and pancreatic carcinoma cells. [13] Green tea was shown to be an aromatase inhibitor in rat; [14] a causative factor for an increase in testosterone level.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Green Tea on the Body Weight and Histoarchitecture of the Testis of Adult Male Sprague dawley Rats

As¹,

R²,

Ao³

et al. 2019

IJCEP

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Background and Aim: Green tea is an aromatic beverage derived from the cured leaves of Camellia sinensis. It is a potent herb which serves various therapeutic purposes. This study was carried out to determine the effect of the administration of various concentration of green tea extract (GTE) on the histoarchitecture of the testis of Sprague dawley adult male rat. Methods: 20 animals were divided into four groups, comprising of 5 animals each. The control group was given distilled water while the treated groups were given 2ml/kg, 4ml/kg and 6ml/kg of aqueous extract of green tea respectively for 26 days. At the end of the administration on the 27th day, in accordance with IACUC regulation, the animals were euthanized following the administration of AGTE after which they were dissected and the testes were excised for tissue processing. Results: There was a progressive decrease in weight of the treated animals corresponding to the increase in the concentration of green tea. The histological analysis showed that the GTE at 2ml/kg did not disrupt the histoarchitecture of the testicular tissue; however, there was mild to moderate degeneration at 4ml/kg and 6ml/kg respectively and this histoarchitectural distortions of the testis by of GTE may take a direct or indirect path; thus, may induce testicular dysfunction. The Feulgen stain intensity was more in the control and group 1, when compared to group 2 and 3, which is a pointer to DNA material loss in testicular tissues at higher doses. Conclusion: Lower dose of GTE may seem beneficial; however higher doses pose more harm in a short period, when compared to the benefit of the lower dose on the body and testicular tissue. However, there is the need for further investigation on the role and mechanism of action of GTE on testicular cellular and tissue dysfunction and consequence on reproduction.

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Tea consumption and the risk of ovarian cancer: A meta-analysis of epidemiological studies

Cited by 19 publications

References 44 publications

Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism

Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism

Anemia and the outcomes in renal transplant recipients: a meta-analysis

The Effects of Green Tea on the Body Weight and Histoarchitecture of the Testis of Adult Male Sprague dawley Rats

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