Tea Consumption is Associated with an Increased Risk of Hyperuricemia in an Occupational Population in Guangdong, China

Abstract

Purpose Chronic hyperuricemia leads to long-term deposition of monosodium urate crystals that may damage the joint structure and affect quality of life. Although hyperuricemia prevalence varies, most studies indicate increased cases of hyperuricemia worldwide. The relationship between hyperuricemia and tea consumption is uncertain. This cross-sectional study investigated the effect of tea consumption on the risk of hyperuricemia in the working population in Guangdong, China. Patients and Methods Data on weight, height, blood pressure, laboratory test results, and health questionnaire responses of 7644 adults aged ≥18 years were obtained from the health examinee dataset of Nanfang Hospital. The characteristics of subjects with and without hyperuricemia were compared using t -tests or non-parametric Mann–Whitney U -tests for continuous variables and chi-square tests for categorical variables. Relationships between hyperuricemia and participant characteristics (sex, age, education level, smoking history, alcohol consumption, hypertension, body mass index, tea consumption, and other dietary factors) were examined using univariate and multivariate logistic regression models to identify independent risk factors for hyperuricemia. Results Tea consumption was associated with a higher risk of hyperuricemia in the crude model (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.48–2.05, once a month through twice a week vs never, P <0.001; OR 2.44, 95% CI 2.07–2.89, ≥3 times a week vs never, P <0.001). The adjusted OR for hyperuricemia was 1.30 (95% CI 1.08–1.56, P =0.006) in participants who consumed tea once a month through twice a week and 1.35 (95% CI 1.11–1.64, P =0.003) in those who consumed tea ≥3 times a week compared with the “never” reference group after adjusting for sociodemographic factors, anthropometric and biochemical indices, and dietary factors. This relationship remained significant in men but not women in subgroup analysis. Conclusion Tea consumption is an independent risk factor for hyperuricemia and is more pronounced in men than women.

Interaction of Harmful Alcohol Use and Tea Consumption on Hyperuricemia Among Han Residents Aged 30–79 in Chongqing, China

“…Third, the health status of the study participants could have influenced their SUA levels. 23 Previous studies have demonstrated associations between hyperuricemia and cardiovascular disease, renal disease, diabetes, hypertension, and other diseases. 4 The mechanism of the effect of tea consumption on hyperuricemia requires further research.…”

“… 41 Some overlooked substances in tea might increase the SUA level, and overconsumption of tea could have harmful effects. 23 Especially, overconsumption of tea may further accelerate the production of uric acid and reduce the excretion of uric acid after harmful alcohol use. The interaction of harmful alcohol use and tea consumption on hyperuricemia among female residents was greater than that among male residents.…”

“… 22 A recent study reflected that tea consumption was associated with the risk of hyperuricemia in an occupational population. 23 Yet, the epidemiological data that can prove such hypotheses about the association between consumption of tea or alcohol and HU are scarce. Furthermore, in the real world, the consumption of tea and alcohol consumption would not be independent, while the interaction between consumption of tea and harmful alcohol use on HU has not gained enough attention and remains unclear.…”

Association between sarcopenia‐related markers and cholelithiasis: A prospective and Mendelian randomization study

“…As one of the most prevalent diseases within the digestive system, risk factors for cholelithiasis encompass aging, obesity, lack of physical activity, and other lifestyle elements. 3,[8][9][10] Sarcopenia stands as a progressive, generalized skeletal muscle disorder, primarily characterized by a swift deterioration of muscle mass and function, 11 with an overall prevalence rate of 10%. 12 Consequently, the potential impact of both the quantity and quality of muscular tissue on human health is increasingly under scrutiny.…”