Tea extracts protect normal lymphocytes but not leukemia cells from UV radiation-induced ROS production: An EPR spin trap study

Çam, Semra Tepe; Polat, Mustafa; Eşmekaya, Meriç Arda; Canseven, Ayşe G.; Seyhan, Nesrin

doi:10.3109/09553002.2015.1047989

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…In addition, tissue damage caused by acute UVB is due to the apoptosis, inflammation and oxidative damage of keratinocytes, leading to epidermis damage and the loss of barrier function [ 11 , 12 ]. In recent years, different types of drugs (including traditional Chinese medicines and plant extracts) have been investigated for the treatment and prevention of skin photoaging with some success [ 13 , 14 , 15 , 16 , 17 , 18 ]. The HaCaT cell photodamage model confirmed that UVB radiation can cause cell nucleus and mitochondrial DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage

Xu¹,

Zhang²,

Wang³

et al. 2018

IJMS

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Quetiapine is a new type of antipsychotic drug, with effective protection of pheochromocytoma PC12 cells from oxidative stress-induced apoptosis. Ultraviolet-B radiation can increase reactive oxygen species (ROS) production, resulting in significant inflammatory responses in damaged skin. Thus, the purpose of this study is to explore whether quetiapine protects the skin from intermediate-wave ultraviolet (UVB)-induced damage through antioxidant stress. In vivo, we found quetiapine treatment was able to significantly decrease skin thickness, erythema, and edema, as well as inflammation compared to control group. Moreover, quetiapine treatment increased the activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). In addition, it reduced the production of malondialdehyde (MDA), a kind of oxidized lipid. In vitro, we found that quetiapine blocked UVB-induced intracellular ROS generation and maintained the cell activity at a normal level. Furthermore, we tested the phosphorylation of p38 both in vivo and in vitro, and we found that quetiapine could inhibit phosphorylation of p38, which is caused by UVB irradiation. We concluded that quetiapine was able to relieve UVB-induced skin damage through its antioxidative properties. These effects might be associated with p38 MAPK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage

Xu¹,

Zhang²,

Wang³

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…Depending on the degree of fermentation and the manufacturing process, China’s tea can be classified into four categories: non-fermented (green tea), semi-fermented (oolong tea), fully-fermented (black tea) and post-fermented (dark tea) [ 3 ]. The protective effects of both black tea and green tea on radiation damages have been reported extensively [ 4 , 5 ]. Some extracts such as tea polyphenols and epigallocatechin gallate have also been proved to mitigate radiation injuries [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity

Long

Zhang

Dong

et al. 2018

Journal of Radiation Research

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The hematopoietic system is widely studied in radiation research. Tea has been proved to have antioxidative activity. In the present study, we describe the protective effects of dark tea extract (DTE) on radiation-induced hematopoietic injury. DTE administration significantly enhanced the survival rate of mice after 7.0 and 7.5 Gy total body irradiation (TBI). The results showed that DTE not only markedly increased the numbers and cloning potential of hematopoietic cells, but also decreased DNA damages after mice were exposed to 6.0 Gy total body irradiation (TBI). In addition, DTE also decreased the levels of reactive oxygen species (ROS) in hematopoietic cells by inhibiting NOX4 expression and increasing the dismutase, catalase and glutathione peroxidase in livers. These data demonstrate that DTE can prevent radiation-induced hematopoietic syndromes, which is beneficial for protection from radiation injuries.

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Clinical Probes for ROS and Oxidative Stress

Zamora

Villamena

2020

Measuring Oxidants and Oxidative Stress in Biological Systems

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Tea extracts protect normal lymphocytes but not leukemia cells from UV radiation-induced ROS production: An EPR spin trap study

Abstract: These results showed that UV radiation induced free radical formation in normal human lymphocytes and indicated that tea extracts may be useful as photoprotective agents for them. On the other hand, tea extracts facilitated free radical production in leukemia cells.

Cited by 5 publications

References 36 publications

Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage

Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage

Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity

Clinical Probes for ROS and Oxidative Stress

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