Tea polyphenol EGCG ameliorates obesity-related complications by regulating lipidomic pathway in leptin receptor knockout rats

Wu, Guohuo; Cheng, Hui‐Ling; Guo, Huimin; Li, Zhuang; Li, Daxiang; Xie, Zhongwen

doi:10.1016/j.jnutbio.2023.109349

Cited by 14 publications

(1 citation statement)

References 80 publications

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“…[ 51 ]. In this context, AOX therapy using natural compounds in the diet, especially phenolic compounds, has been proven to be an effective and safe approach to addressing the consequences of ROS in obesity [ 52 , 53 , 54 , 55 ]. More concisely, the AOX activities of these compounds depend not only on their scavenger activity but also on their ability to prevent the activation of transcriptional factors such as NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) and reduce the expression of target genes, including those involved in inflammation [ 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

et al. 2023

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Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the hepatic biological rhythm and induce important ROS production. Consequently, we aimed to elucidate whether grape seed proanthocyanidin extract (GSPE) administration recovers the CAF-induced hepatic antioxidant (AOX) misalignment and characterize the chronotherapeutic properties of GSPE. For this purpose, Fischer 344 rats were fed a standard diet (STD) or a CAF and concomitantly treated with GSPE at two time-points (ZT0 vs. ZT12). Animals were euthanized every 6 h and the diurnal rhythms of hepatic ROS-related biomarkers, hepatic metabolites, and AOX gene expression were examined. Interestingly, GSPE treatment was able to recover the diurnal rhythm lost due to the CAF. Moreover, GSPE treatment also increased the acrophase of Sod1, as well as bringing the peak closer to that of the STD group. GSPE also corrected some hepatic metabolites altered by the CAF. Importantly, the differences observed at ZT0 vs. ZT12 due to the time of GSPE administration highlight a chronotherapeutic profile on the proanthocyanin effect. Finally, GSPE could also reduce diet-induced hepatic oxidative stress not only by its ROS-scavenging properties but also by retraining the circadian rhythm of AOX enzymes.

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Section: Discussionmentioning

confidence: 99%

Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

et al. 2023

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Tea Polyphenols Reduced Obesity by Modulating Gut Microbiota‐SCFAs‐Barrier and Inflammation in High‐Fat Diet‐Induced Mice

Tian,

Huang,

Pan

et al. 2024

Molecular Nutrition Food Res

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ScopeObesity by high‐fat diets (HFDs) is a chronic metabolic disorder that poses a significant threat to human health. Tea polyphenols (TPs) can prevent obesity caused by HFD by modulating gut microbiota.Methods and resultsTo explore the function of TP in mitigating the effects of obesity and inflammation, mice are fed HFDs either with or without TP. TP supplementation effectively attenuates HFD‐induced weight gain, liver and adipose tissue accumulation, while also improving liver fat content as well as colon and ileum tissue morphology. TP supplementation leads to a downregulation of lipid accumulation genes and an upregulation of lipid‐decomposition genes. Moreover, TP increases Blautia and Faecalibaculum while reducing the Colidextribacter and short‐chain fatty acids in HFD‐induced mice, significantly activates G protein‐coupled receptors, inhibits histone deacetylases, enhances intestinal tight junction expression levels, reduces intestinal permeability, and thereby preserves intestinal barrier integrity. Additionally, TP markedly suppresses the expression of inflammatory cytokines and inhibits the activation of TLR4 signaling pathways.ConclusionThese findings suggest that TP holds great promise for improving both obesity management and alleviating intestinal inflammation, and provides a clue for understanding the antiobesity effects of TP.

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Green tea polyphenols alleviate β-conglycinin-induced anaphylaxis by modulating gut microbiota in rats

Zhou,

Zheng,

Yang

et al. 2023

Food Bioscience

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Tea polyphenol EGCG ameliorates obesity-related complications by regulating lipidomic pathway in leptin receptor knockout rats

Cited by 14 publications

References 80 publications

Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats

Tea Polyphenols Reduced Obesity by Modulating Gut Microbiota‐SCFAs‐Barrier and Inflammation in High‐Fat Diet‐Induced Mice

Green tea polyphenols alleviate β-conglycinin-induced anaphylaxis by modulating gut microbiota in rats

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