Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1

Manna, Sukumar; Mukherjee, Sudeshna; Roy, Anup; Das, Sukta; Panda, Chinmay K.

doi:10.1016/j.jnutbio.2008.04.001

Cited by 43 publications

(21 citation statements)

References 55 publications

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“…Tea catechins were found to exhibit inhibitory effects against the formation and development of various tumors. More specifically, tea catechins have been reported to alter the expression of C-MYC in lung carcinogenesis (29). Their anticancer effects include suppressing cell proliferation, promoting apoptosis, modulating signaling transduction and inhibiting cell invasion or metastasis (30).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Zhong

Dong

Yang

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Green tea catechins are known to function as anticancer agents via inhibition of carcinogenesis during the initiation, promotion and progression stages. Many potential mechanisms have been proposed, yet the precise mechanism of lung cancer prevention by green tea catechins remains unclear. microRNAs (miRs) are a class of 21-24 nucleotide small non-coding RNAs and play critical roles throughout cellular development and regulation. Emerging evidence demonstrates that tea catechins influence the expression of miRs in human cancer cells to inhibit tumorigenesis. Both let-7a-1 and let-7g were detected in the human lung cancer cells treated with tea catechins. The cell viability and cell cycle were analyzed after tea catechins treatment. In the present study, we found that tea catechins upregulated the tumor-suppressor miRs, let-7a-1 and let-7g, in lung cancer cell lines. The upregulation of let-7a/7g repressed the expression of their targets, C-MYC and the regulatory protein of LIN-28, at the mRNA and protein levels. Moreover, the cell growth assay indicated that tea catechins significantly inhibited cell proliferation, and the flow cytometric analysis revealed an increase in the number of cells in the G2/M phase and a decrease in the number of cells in the S phase after treatment with tea catechins. These observations suggest that green tea catechins mediate the inhibition of proliferation of lung cancer cells through the let-7 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Zhong

Dong

Yang

et al. 2012

Experimental and Therapeutic Medicine

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“…Knockdown of JAM-A decreased protein levels of CCND1 . Tea polyphenols (Natural compound): Epigallocatechin gallate, epicatechin gallate and theaflavin reduced the expression of CCND1 in benzo(a)pyrene-induced lung carcinogenesis in mice (Manna et al, 2009). Polydatin: PD suppressed expression of CCND1 in A549 and NCI-H1975 lung cancer cell lines .…”

Section: Lung Cancermentioning

confidence: 99%

CCND1 (B-cell leukemia/lymphoma 1)

Sarkar¹,

Panda²

2017

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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“…51 Five studies found green tea to increase animal survival in vivo, 29,44,50,54,55 and 3 studies showed growth inhibitory effects on in vivo tumors. 30,40,41 In vitro, the most supported mechanisms were: growth inhibition and/or antiproliferative activity in tumor cells (n = 24), 23,24,31,34,44,[64][65][66][67][68][69]71,75,80,[84][85][86][90][91][92][93]95 proapoptotic activity in tumor cells (n = 17), 8,23,30,34,44,69,[71][72][73][74]77,79,80,83,86,90,91,97 and anti-invasive, antimetastatic activity (n = 14). …”

Section: Preclinical Evidencementioning

confidence: 99%

Green Tea and Lung Cancer

et al. 2012

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Background: Green tea is a beverage widely used by lung cancer patients and the public for its purported anticancer properties. The authors conducted a systematic review of green tea for the treatment and prevention of lung cancer. Methodology: Six electronic databases were searched from inception until November 2011 for human interventional and preclinical evidence pertaining to the safety and efficacy of green tea for lung cancer. Results: A total of 84 articles met inclusion criteria: two Phase I trials, three reports of one surrogate study, and 79 preclinical studies. There is a lack of controlled trials investigating green tea for lung cancer. Two Phase I studies showed no objective tumor responses at the maximum tolerated dose, ranging from 3 to 4.2 g/m 2 green tea extract (GTE) per day. Four cups of green tea daily decreased DNA damage (8OH-dG) in smokers. Human studies indicate that 800mg of green tea catechins daily does not alter activity of the CYP2D6, CYP1A2, CYP3A4 and CYP2C9 enzymes, however in vitro evidence suggests that green tea may bind to and reduce the effectiveness of bortezomib. Green tea applied topically may improve the healing time of radiation burns. Conclusions: Although some evidence suggests that chemopreventative benefits can be accrued from green tea, there is currently insufficient evidence to support green tea as a treatment or preventative agent for lung cancer. Green tea should not be used by patients on bortezomib therapy. Further research is warranted to explore this natural agent for lung cancer treatment and prevention.

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Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1

Cited by 43 publications

References 55 publications

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7

CCND1 (B-cell leukemia/lymphoma 1)

Green Tea and Lung Cancer

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