Tea tree oil reduces histamine-induced skin inflammation

Koh, K. J.; Pearce, Annette; Marshman, Gillian; Finlay‐Jones, John J.; Hart, Prue H.

doi:10.1046/j.1365-2133.2002.05034.x

Cited by 157 publications

(89 citation statements)

References 15 publications

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“…When the effect of TTO on hypersensitivity reactions involving mast cell degranulation was examined in mice, TTO and terpinen-4-ol applied after histamine injection reduced histamine-induced skin edema, and TTO also significantly reduced swelling induced by intradermal injection of compound 48/80 (24). Human studies on histamine-induced wheal and flare provided further evidence to support the in vitro and animal data, with the topical application of neat TTO significantly reducing mean wheal volume but not mean flare area (97). Erythema and flare associated with nickel-induced contact hypersensitivity in humans are also reduced by neat TTO but not by a 5% TTO product, product base, or macadamia oil (119).…”

Section: Anti-inflammatory Activitymentioning

confidence: 49%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

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SUMMARY Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.

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Section: Anti-inflammatory Activitymentioning

confidence: 49%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

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“…The TTO has been shown to have a number of therapeutic properties including anti-inflammatory activity (13)(14)(15). However, it is best known for its antimicrobial activity against a broad spectrum of microorganisms, including oral ones, for example Staphylococcus aureus and some viruses, including herpes simplex virus and flu viruses.…”

Section: Biological Propertiesmentioning

confidence: 99%

A Comparative Study of Antibacterial and Anti-Inflammatory Effects of Mouthrinse Containing Tea Tree Oil

Salvatori

Barchi²,

Guzzo

et al. 2017

ORL

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SUMMARYThe study evaluated the antibacterial and anti-inflammatory efficacy, domiciliary oral hygiene, of a mouthrinse containing Tea Tree Oil (TTO) comparing it with two mouthrinses containing chlorhexidine 0,12% respectively and essential oils, and a placebo. Materials and methods. A pilot study, randomized 4 × 4, controlled, cross-over, double-blind. 16 subjects with gingivitis (7 males and 9 females) aged 21-37 years, were randomly divided into four groups based on mouthwash that had to be used for domiciliary oral hygiene: mouthwash with essential oils, mouthwash with chlorhexidine 0,12 %, mouthwash containig tea tree oil and mouthwash placebo. Clinical evaluation was performed by: Full Mouth Plaque Score (FMPS), Full Mouth Bleeding Score (FMBS), Gingival Index (GI), discolorations, language examination and alteration of taste. The data were recorded before and 2 weeks after treatment.Results. Statistical analysis shows that treatments with tea tree oil, essential oils and chlorhexidine are effective. Comparing treatments should be noted that the tea tree oil gives a greater improvement in the GI and FMBS, while it is the least effective in the control of bacterial plaque. Conclusion. Although further studies are needed, the anti-inflammatory properties of the mouthwash made from TTO would seem to be a valuable non-toxic adjunct in the management of gingivitis.

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“…Among them, the essential oil of Melaleuca alternifolia, also known as TTO (tea tree oil), stands out due to its broad spectrum of action [6]. In Australia, it is commonly used as a topical therapeutic agent and its medical use is primarily related to its anti-inflammatory [7,8] and antimicrobial [9,10] actions. The use as a topical analgesic agent is supported by an increasing clinical data indicating that TTO is effective in the treatment of infections or diseases such as herpes [11], acne [12], dandruff [13] and oral candidiasis [14][15][16].…”

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confidence: 99%

Effect of Melaleuca Alternifolia and Its Components on Candida Albicans and Candida Tropicalis

Francisconi¹,

Bordini²,

Nogueira³

et al. 2015

UCMS

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Abstract:The essential oil of Melaleuca alternifolia is an herbal antifungal action and preventive scale pharmaceutical or cosmetic. The aim of this study was to evaluate the efficacy of Melaleuca alternifolia (tea tree oil-TTO) and its component (Terpinen-4-ol) on Candida albicans and Candida tropicalis in planktonic and biofilm form of dual species. MIC (Minimum Inhibitory Concentration) and MFC (Minimum Fungicidal Concentration) were determined of single species. Biofilms were quantified in CFU (colony forming unit per mL) and XTT {2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide} cell viability assay in single and multiple species. MIC was TTO (0.25%) and Terpinen-4-ol (0.11%) for both species. The MFC for Candida albicans showed TTO (0.25%) and Terpinen-4-ol (0.11%) were capable of inhibiting the growth and for Candida tropicalis was 0.50% and 0.24%, respectively. The results on biofilm for Candida albicans in single species and multiple species showed TTO (0.5%) and Terpinen-4-ol (0.24%) were effective. For Candida tropicalis in single species, treatments with TTO (0.5%) and Terpinen-4-ol (0.47%) were effective. For multiple species, the treatments with TTO (0.5%) and Terpinen-4-ol (0.24%) were also effective. In the XTT test, for Candida albicans in single species: TTO (0.25%) and Terpinen-4-ol (0.24%). For Candida tropicalis, the results were TTO (0.5%) and Terpinen-4-ol (0.11%), while for multiple species were TTO (0.25%) and Terpinen-4-ol (0.11%). Based on these factors, Candida spp. are susceptible to the antimicrobial agents TTO and Terpinen-4-ol, suggesting that these compounds might be beneficial as therapeutic.

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Tea tree oil reduces histamine-induced skin inflammation

Abstract: This is the first study to show experimentally that tea tree oil can reduce histamine-induced skin inflammation.

Cited by 157 publications

References 15 publications

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

A Comparative Study of Antibacterial and Anti-Inflammatory Effects of Mouthrinse Containing Tea Tree Oil

Effect of Melaleuca Alternifolia and Its Components on Candida Albicans and Candida Tropicalis

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