The predictors of academic achievement and self-regulation in 95 high-risk children studied from birth were investigated during the second grade. Parenting, early maternal adjustment, child adjustment and temperament were hypothesized to predict the emergence of self-regulation. Although parenting, maternal adjustment, and child adjustment were related to achievement and classroom adjustment, they were not related to children's self-regulation, which was the strongest predictor of teacher ratings of academic performance, standardized achievement in math and reading, and classroom adjustment.