The purpose of this research was to study the environment and guidelines of administration to develop innovators among secondary science teachers at Saint Gabriel's Foundation, Thailand. Quantitative and qualitative researches were used and research tools were questionnaires and open-ended questions. The data has been gathered from 11 secondary school directors, 110 staff at the management level and 149 secondary science teachers at Saint Gabriel's Foundation, Thailand in the academic year 2020. The quantitative data was analyzed by descriptive statistic, whereas content analysis was used to analyze qualitative data. Results indicated that strengths of the environment to develop innovators among secondary science teachers were school systems, management styles of directors, creativity skills of teachers, critical thinking skills, information technology and communication skills, share value, participatory work and teamwork. The weaknesses were school strategies and structures obstructing innovator development of teachers, lack of innovative process knowledge, and entrepreneurial and financial skills. The opportunities were technological advancement, social and political conditions that affected the development of innovators. The threat was the slowdown of economic conditions of students’ families and communities. According to the study, the five guidelines for the development of innovators among secondary science teachers, developing school strategies, developing school structure, promoting teacher innovator development, learning and coaching, and networking were found.