Advancing inclusive education in countries where children with special needs (CWSNs) are yet to be meaningfully included in regular schools will ensure the progress of Goal 4 of the Sustainable Development Goals. One potent determinant to the effective inclusion of CWSNs is teachers’ intention and efforts to integrate them into their classes. Yet, there is still inadequate evidence in the existing body of literature that will help stakeholders understand the psychosocial variables that will impact their intentions and efforts to include CWSNs in their classes. In view of this, our study determined the association between teachers’ sociodemographic characteristics, psychological distress, job satisfaction, and their willingness to include CWSNs in their classes using a hierarchical regression model. The sample size is made up of 502 secondary school teachers in Anambra State. Our model showed the potency of sociobiological and motivational factors on teachers’ inclusive education willingness of CWSNs in their classes. Teachers’ age, years of teaching experience, and job satisfaction are significant predictors of their inclusion willingness for CWSNs. Teachers’ psychological distress did not significantly predict their inclusion willingness for CWSNs. The significance and implications of our findings were underscored.