Teaching Analytical Chemistry to Pharmacy Students: A Combined, Iterative Approach

Masania, Jinit; Grootveld, Martin; Wilson, Philippe B.

doi:10.1021/acs.jchemed.7b00495

Cited by 13 publications

(20 citation statements)

References 27 publications

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“…), which is expensive and technically challenging. Benchtop NMR spectrometers therefore offer low-cost and user-friendly options to monitor reactions in both teaching [57] and research laboratory environments [58]. In 2015, Cronin and co-workers not only tracked reaction progress by monitoring starting materials and products using a benchtop NMR system, but also incorporated a feedback loop mechanism in order to modify the reaction composition, allowing reaction efficiency to be explored and optimised in real-time [31].…”

Section: Reaction Monitoring and Chemical Transformationsmentioning

confidence: 99%

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Grootveld

Percival

Gibson

et al. 2019

Analytica Chimica Acta

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136

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The employment of spectroscopically-resolved NMR techniques as analytical probes have previously been both prohibitively expensive and logistically challenging in view of the large sizes of high-field facilities. However, with recent advances in the miniaturisation of magnetic resonance technology, low-field, cryogen-free "benchtop" NMR instruments are seeing wider use. Indeed, these miniaturised spectrometers are utilised in areas ranging from food and agricultural analyses, through to human biofluid assays and disease monitoring. Therefore, it is both intrinsically timely and important to highlight current applications of this analytical strategy, and also provide an outlook for the future, where this approach may be applied to a wider range of analytical problems, both qualitatively and quantitatively.

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Section: Reaction Monitoring and Chemical Transformationsmentioning

confidence: 99%

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Grootveld

Percival

Gibson

et al. 2019

Analytica Chimica Acta

Self Cite

136

View full text Add to dashboard Cite

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“…These facilities operating at LF suffer from the same issues of sensitivity which plagued early designs of NMR spectrometers [21]; however, with the employment of approaches such as solvent suppression [22] and magnet arrays [23], it is possible to simultaneously observe and monitor 20 or more metabolites in human saliva and urine at LF, as demonstrated here for the first time. Although this limits the detection capabilities of NMR when compared to those of larger, high-field instruments, the advantages of more compact, mobile NMR instruments, incorporating applications of chemometric/metabolomics approaches to the multivariate analysis of complex mixtures, have been demonstrated in fields such as materials science [24], forensic chemistry [25], chemical education [26] and biomedical sciences in general.…”

Section: Introductionmentioning

confidence: 99%

Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models

et al. 2018

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Novel sensing technologies for liquid biopsies offer promising prospects for the early detection of metabolic conditions through omics techniques. Indeed, high-field nuclear magnetic resonance (NMR) facilities are routinely used for metabolomics investigations on a range of biofluids in order to rapidly recognise unusual metabolic patterns in patients suffering from a range of diseases. However, these techniques are restricted by the prohibitively large size and cost of such facilities, suggesting a possible role for smaller, low-field NMR instruments in biofluid analysis. Herein we describe selected biomolecule validation on a low-field benchtop NMR spectrometer (60 MHz), and present an associated protocol for the analysis of biofluids on compact NMR instruments. We successfully detect common markers of diabetic control at low-to-medium concentrations through optimised experiments, including α-glucose (≤2.8 mmol/L) and acetone (25 µmol/L), and additionally in readily accessible biofluids, particularly human urine. We present a combined protocol for the analysis of these biofluids with low-field NMR spectrometers for metabolomics applications, and offer a perspective on the future of this technique appealing to ‘point-of-care’ applications.

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“…Smartphone-free voting platforms of the type used in this study help ensure that students are engaging with both their work and peers within these problem-solving sessions rather than relying on access to web-based search engines, which may hinder the learning experience and create a distraction, especially in large classroom environments where use on off-topic tasks is harder to monitor. − Smartphone-free voting is also preferable when working with students in chemistry laboratories where mobile phone usage is often prohibited on safety grounds.…”

Section: Introductionmentioning

confidence: 99%

Clickers versus Plickers: Comparing Two Audience Response Systems in a Smartphone-Free Teaching Environment

Pearson

2020

J. Chem. Educ.

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This study compared the performance of two audience response systems (ARSs) without students requiring smartphone technology or Internet access during problem-based learning (PBL) activities. Clicker handsets linked to a radio frequency (RF) receiver and paper voting cards, known as Plickers, which display a QR code (two-dimensional barcode) that can be captured by the instructor using a standard camera on a tablet device, represent two audience response platforms that allow students to vote in classrooms where smartphones are prohibited. Following regular usage of both by 157 first-year undergraduates, the proportion of the cohort voting with each polling platform was compared across 65 polling events as a measure of student compliance and engagement, and by deduction ARS performance. Results from this study showed that both clickers and Plickers achieved satisfactory cohort compliance rates of 87.22% and 78.26%, respectively. Anonymous student survey data overwhelming favored the clicker handsets over the Plicker voting cards, which was, in part, justified by clicker usage being more self-explanatory than that of Plickers; however, from an instructor’s perspective, both voting platforms adequately captured the level of students’ understanding during interactive sessions where problem-solving opportunities were embedded while maintaining a smartphone-free environment.

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Teaching Analytical Chemistry to Pharmacy Students: A Combined, Iterative Approach

Cited by 13 publications

References 27 publications

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models

Clickers versus Plickers: Comparing Two Audience Response Systems in a Smartphone-Free Teaching Environment

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