Teaching Cases from the Royal Marsden Hospital Case 9: An elderly patient with unusual circulating cells

Brace, William; Bain, Barbara J.; Walker, Marjorie M.; Catovsky, Daniel

doi:10.3109/10428199509059656

Cited by 8 publications

(1 citation statement)

References 4 publications

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“…In human medicine, just over 30 cases have been reported since 1960. The primary neoplasias were mainly cancers of the breast (13 cases), then small cell lung (8), colorectal (2), Merkel cell (2), transitional cell carcinoma (1), and a carcinoma of undetermined origin (1). Moreover, 2 cases involving melanoma and 2 cases involving rhabdomyosarcoma were reported.…”

Section: Discussionmentioning

confidence: 99%

Carcinocythemia: First report in a cat and literature review

Lemos¹,

Carvalho²,

Costa

et al. 2018

Veterinary Clinical Pathol

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A 6-year-old female neutered European Shorthair cat was presented with a 2-day history of lethargy and hyporexia. On physical examination, the cat was slightly depressed and had a 2.5 cm nodule in the left 3 mammary gland. The hemogram revealed mild leukocytosis with mature neutrophilia and moderate thrombocytopenia. On blood smear evaluation, rare pleomorphic cells, possibly of epithelial origin, were observed mainly at the feathered edge. The animal died about 12 hours after presentation, and a necropsy was performed. On histopathology, the mammary nodule was diagnosed as a tubulopapillary adenocarcinoma with vascular invasion and widespread metastases. Immunocytochemical tests for cytokeratins (AE1/AE3) confirmed the epithelial phenotype of the neoplastic cells observed on the blood smear. The present report describes a feline mammary carcinoma with widespread metastases and the presence of malignant epithelial cells in the peripheral blood referred to as carcinocythemia. This condition has been previously described in people and dogs. To the author's knowledge, this is the first reported case of feline carcinocythemia. As in other species, the phenomenon was associated with a terminal phase of systemic malignancy.

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