This paper is intended to explicate an education model developed as a response to the challenges posed by the advancement of science and technology in Industry 4.0 era. As has been well-documented, industry revolutions have always brought about new challenges to education. The invention of paper has hanged oral to written tradition of doing education (in Industry 1.0), followed by mass education at schools and universities (in Industry 2.0), and ICT based education (in Industry 3.0), have radically changed the ways of doing education. In Industry 4.0, new alternatives are now of high demand. In this relation, a set of principles developed out of some review of related research findings and theoretical thoughts has been formulated and will be explicated in this paper. In other words, throughout this paper, the alternative education model for learning excellence in Industry 4.0 and disruptive era, called SMEMFLE I 4.0 DE, standing for Synergetic, Multilayered, Educational Model for Learning Excellence in Industry 4.0 and Disruption Era will be presented, illustrated, and supported by related research findings. From the explication, it can be concluded that the model is not only plausible, but also enlightening.