In order to ensure the quality of resource recommendation and solve the problems of low recommendation accuracy, long recommendation time, and high data loss rate in the process of resource recommendation in traditional methods, a personalized recommendation system of English teaching resources based on the multi-K nearest neighbor regression algorithm is designed. According to the overall architecture of the personalized recommendation system of teaching resources, this study designs the resource browsing function module, teaching resource detailed page recommendation module, and teaching resource database. Based on the basic idea of the multi-K nearest neighbor regression algorithm, in order to avoid the loss of important data in English teaching resource recommendation and reduce the data loss rate, a missing data reconstruction algorithm of English teaching resources is proposed. Finally, the path interest of student users is considered from the selection of browsing path and access time to realize the personalized recommendation of English teaching resources. The experimental results show that the system has high resource recommendation accuracy, short recommendation time, and low data loss rate.