In his May 1, 1971, presidential address to the Society for Pediatric Research, William L. Nyhan coined the term "behavioral phenotype" (Nyhan, 1972). His plan for the talk was to discuss his observations that children who shared a genetic syndrome (i.e., Cornelia de Lange and Lesch-Nyhan syndromes) exhibited common patterns of atypical behaviors. Nyhan presumed these behaviors to be genetically determined and believed that additional research could both lead to improvements in the "diagnosis and management" of individuals with specific syndromes and "yield information of fundamental biologic importance" (p. 1). Nearly a quarter of a century later, Nyhan described the first published text focused on behavioral phenotypes (Nyhan, 1995) as "a coming of age for the field" (p. x). He hoped the volume would stimulate additional research that would deepen understandings of the mechanisms through which genes influence behavior and lead to more effective treatments for affected individuals. Hodapp and Ricci (2002), writing 7 years later in a followup volume, lauded the field's progress toward understanding how different genetic intellectual disability (ID) disorders could differentially effect behavior; however, they described the failure of translating this knowledge into educational practice as "the unrealized connection" (p. 137). Since then, several researchers (Fidler, 2005; Lemons & Fuchs, 2010) have suggested that behavioral phenotypes could be used to guide the development of interventions targeted toward groups of individuals with a common genetic syndrome. Although this line of work has several challenges (e.g., variability of profiles within a syndrome, characteristics shared across syndromes; Dykens, 1995; Reilly, 2012), pursuing Nyhan's goal to improve intervention for individuals with a shared genetic syndrome has potential to enhance outcomes. Purpose The purpose of this study was to evaluate the feasibility and potential efficacy of an early reading intervention targeting 618941F OAXXX10.