For the sake of media literacy and public opinion response ability of college teachers, research on media literacy and public opinion response ability of college teachers based on big data technology is proposed. To summarize and define teachers’ media literacy and public opinion response-ability, literature review and consulting experts in related fields are employed. Based on the survey questionnaire to obtain the research data and using a combination of correlation analysis and regression analysis, the media literacy and public opinion response ability of college teachers driven by big data technology are analyzed by examples. After analysis, it can be obtained that there is a significant positive correlation between the independent variables and the dependent variables, with a P-value of less than 0.05, and their corresponding regression equations are 1.238 + 0.868* media cognitive ability (X1) + 0.663* media application and creativity ability (X2) + 0.856* critical acceptance of media information (X3) + 0.854* curricular integration ability (X4) + 0.988* Precautionary Awareness (X5) + 0.433* Speed of Dealing with Problems (X6) + 0.599* Program Rationality (X7). This study fully reveals the mechanism of improving the media literacy and public opinion response ability of college teachers, driven by big data, which is of great significance in promoting the development of college education.