Tear Film Lipid Layer Changes Following Combined Effect of Heated Eye Mask with Intense Pulsed Light Therapy for Evaporative Dry Eye: A Randomized Control Study

Li, Liangzhe; Chen, Jiayan; Qin, Guanghao; Qi, Yifan; Chen, Yimeng; Li, Mingze; Zhang, Qing; Cheng, Yuan; Guo, Naici; Moutari, Salissou; Moore, Jonathan E.; Yu, Sile; He, Xingru; Pazo, Emmanuel Eric

doi:10.1089/photob.2023.0051

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…Liangzhe Li et al [ 14 ] underlined in their study that the study group combining IPL treatment with a heated eye mask registered much better results concerning tear film stability and inflammatory response, than the study group under IPL treatment alone. Still, measurements in their study were made only during the IPL treatment, the last ones on day 84 of treatment, and after 3 sessions of IPL therapy, compared to our study that included 4 IPL sessions (as recommended by the manufacturer) and a much longer period of observation and assessment.…”

Section: Discussionmentioning

confidence: 99%

Efficiency of Combining Heated Eye Mask with Intense Pulsed Light Therapy as a Treatment Option for Evaporative Dry Eye Disease

2024

RJO

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Section: Discussionmentioning

confidence: 99%

Efficiency of Combining Heated Eye Mask with Intense Pulsed Light Therapy as a Treatment Option for Evaporative Dry Eye Disease

2024

RJO

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“…Intense pulsed light (IPL) therapy is best known for treating various dermatological conditions, including hypertrichosis, benign cavernous venous malformations, telangiectasia, port wine stains, and other pigmented lesions. 16 , 17 IPL treatment involves the use of a noncoherent polychromatic light source that emits light across a wide range of wavelengths, typically between 500 and 1200 nm, targeting the sebaceous glands located on the surface of the facial skin. 18 It’s postulated that the photothermal impact induced by IPL therapy reduces inflammation and promotes the activation of the meibomian glands and several studies have reported its effectiveness therapy for improving signs and symptoms of DE.…”

Section: Introductionmentioning

confidence: 99%

Management of Glaucoma-Related Dry Eye Disease with Intense Pulsed Light: A Randomized Control Study

Zhang,

Qi,

Chen

et al. 2024

OPTH

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Purpose The objective of this study was to assess the effectiveness of intense pulsed light (IPL) therapy in individuals diagnosed with glaucoma and dry eye disease (DED). Methods This randomized control study recruited 22 individuals diagnosed with glaucoma, ranging in age from 33 to 82 years. These participants were undergoing treatment with hypotensive eyedrops and had clinical indications and subjective complaints associated with dry eye. Each patient underwent three sessions of IPL therapy in one eye, while the contralateral eye served as the control eye (CT). The following parameters were assessed at three time points: baseline, week-2, and week-4. These parameters include non-invasive breakup time (NITBUT), tear meniscus height (TMH), conjunctivocorneal epithelial staining score (CS), tear film lipid layer (TFLL), meibomian gland expressibility score (MGEx), Schirmer I test, ocular bulbar redness score (OBRS), and ocular surface disease index (OSDI). Intraocular pressure (IOP), best-corrected visual acuity (BCVA), and corneal endothelial cell count (ECC) were assessed for safety. The clinical trial was registered on 25/12/2023 at ClinicalTrials.gov website (NCT06158984). Results Comparing baseline and 4-week measurements revealed that the IPL group found significant improvements in NITBUT (IPL: 8.74±2.60 sec. vs CT: 5.76±1.75 sec. p <0.01), TMH (IPL: 0.23±0.05mm vs CT: 0.19±0.06mm, p =0.011), C.S. (IPL: 1.14±0.56 vs CT: 1.95±1.17, p =0.005), TFLL (IPL: 2.91±2.91 vs CT:3.36±0.58, p =0.047), MGEx score (IPL: 1.14±0.35 vs CT: 1.45±0.51, p =0.020) and OSDI scores (IPL: 31.77±15.59 vs 50.59±21.55, p =0.002) significantly improved. Conversely, other parameters showed no significant improvements ( p >0.05). Conclusion The progression of ocular surface disease in individuals using topical anti-glaucoma medication may worsen if the condition is not addressed. Nevertheless, IPL therapy has the potential to result in significant improvements in both objective and subjective measures of dry eye. Best-corrected visual acuity, endothelial cell count, and intraocular pressure were determined to be within the permitted limits. No adverse events were reported during the course of the study.

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Effectiveness and safety of intense pulsed light therapy for dry eye symptoms due to meibomian gland dysfunction—A systematic review and meta‐analysis

Peira,

Ali,

Modén

et al. 2024

Acta Ophthalmologica

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BackgroundDry eye disease is a common ocular condition, affecting quality of life and function for many people worldwide. This systematic review evaluates the effectiveness and safety of intense pulsed light (IPL) therapy for dry eye symptoms due to meibomian gland dysfunction (MGD), as they are not yet established.MethodsComprehensive searches were conducted in January 2024 (Cochrane Library, Embase, MEDLINE). We included randomized controlled studies assessing the effects of IPL on dry eye symptoms or any adverse effects in patients with MGD. Two authors independently screened studies and evaluated the risk of bias. Meta‐analysis (random effects model) and Grading of Recommendations Assessment, Development and Evaluation (GRADE) were used to synthesize results and assess certainty of evidence.ResultsIn total, 13 studies were included in the review. The risk of bias was assessed as moderate in most results primarily due to the risk of selective reporting. The synthesis and GRADE assessment show that IPL probably results in a clinically relevant reduction in symptoms of dry eyes when compared to placebo (MD = −16 OSDI points; 95% CI = −20 to −12). However, whether the effect is clinically relevant when used as an add‐on to standard care is still unclear (MD = −7 OSDI points; 95% CI = −12 to −3). Furthermore, the evidence on adverse events is very uncertain.ConclusionAlthough IPL probably results in a clinically relevant reduction in symptoms of dry eyes when compared to placebo, in practice IPL would typically be used as an add‐on to standard treatment. It is therefore essential with further studies investigating whether this use would give a clinically relevant reduction in symptoms, and what the potential harm of IPL is when treating MGD.

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Tear Film Lipid Layer Changes Following Combined Effect of Heated Eye Mask with Intense Pulsed Light Therapy for Evaporative Dry Eye: A Randomized Control Study

Cited by 3 publications

References 64 publications

Efficiency of Combining Heated Eye Mask with Intense Pulsed Light Therapy as a Treatment Option for Evaporative Dry Eye Disease

Efficiency of Combining Heated Eye Mask with Intense Pulsed Light Therapy as a Treatment Option for Evaporative Dry Eye Disease

Management of Glaucoma-Related Dry Eye Disease with Intense Pulsed Light: A Randomized Control Study

Effectiveness and safety of intense pulsed light therapy for dry eye symptoms due to meibomian gland dysfunction—A systematic review and meta‐analysis

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