Tear protein analysis in patients with primary acquired nasolacrimal duct obstruction treated with lacrimal passage intubation

Yaginuma, Shigeharu; Konno, Kimihito; Shigeyasu, Chika; Yamada, Masakazu

doi:10.1007/s10384-020-00804-6

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…While ANLDO is more prevalent in women, suggesting a potential role for sex hormones in its development, ( 3 ) studies also exist suggesting a lack of effect from sex hormones. ( 4 ) In addition, tear film osmolarity and the content of tear film proteins and lipids have been recognized as influential factors in ANLDO ( 5 , 6 ). Analyses of tear composition have demonstrated significantly elevated levels of pro-inflammatory cytokines in ANLDO patients, contributing to inflammation ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Systemic Inflammation in Acquired Nasolacrimal Duct Obstruction

Dag

2023

Beyoglu Eye J

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Objectives: This study aims to investigate the influence of systemic inflammation on adult patients with acquired nasolacrimal duct obstruction (ANLDO). Methods: Peripheral venous blood analysis was performed on adult patients who underwent dacryocystorhinostomy for ANLDO between June 2020 and December 2022, during their remission period just before the surgery. Platelet, Neutrophil, Lymphocyte, Monocyte, White Blood Cell (WBC) count, Platelet/Lymphocyte ratio (PLR), Neutrophil/Lymphocyte ratio (NLR), Monocyte/Lymphocyte ratio (MLR), and systemic inflammatory index (SII) (calculated as platelet × (neutrophil/lymphocyte)) were compared with a volunteer control group. Results: The study included 54 adult patients with ANLDO and 54 individuals in the control group. The mean age was 42.5±14.4 years in the ANLDO group and 37.8±12.3 years in the volunteer control group. There was no significant difference in age between the groups (p=0.064). Platelet value (295.9±70.9→254.7±43.9), PLR value (143.8±77.7→119.0±36.1), and SII value (534.7±192.0→442.6±212.2) in the ANLDO group were significantly higher compared to the Control group (p=0.000, p=0.023, p=0.020, respectively). Neutrophil, lymphocyte, monocyte, NLR, MLR, and WBC values did not exhibit significant differences between the case and control groups (p=0.299, p=0.469, p=0.125, p=0.419, p=0.143, and p=0.465, respectively). Conclusion: The study revealed elevated systemic platelet counts in ANLDO patients, resulting in higher PLR and SII values. The authors suggest that a histopathological examination to assess the local impact of platelets or other inflammatory processes in nasolacrimal duct obstruction could offer valuable insights into the etiopathology of ANLDO.

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Section: Introductionmentioning

confidence: 99%

The Role of Systemic Inflammation in Acquired Nasolacrimal Duct Obstruction

Dag

2023

Beyoglu Eye J

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“…Because tears travel from the ocular surface to the nasal cavity through the lacrimal drainage system, any changes in the quality or composition of tears may affect the lacrimal system. Therefore, numerous studies have assessed the quantitative and qualitative changes in tear composition in patients with LDOD 4 5 . The results of such studies have been variable in terms of tear meniscus height, volumetric, osmolarity and cytokine levels in tear fluids 5 6 7 8 .…”

mentioning

confidence: 99%

Detection & analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction

Wang

Xiang²,

Hu³

et al. 2021

Indian Journal of Medical Research

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Background & objectives : Tear proteomic changes can be a candidate etiopathogenesis of lacrimal duct obstruction diseases (LDODs). Studies on proteomics have focused primarily on nasolacrimal duct obstruction, and some specific inflammatory cytokines such as interferon (IFN)-α2a, interleukin (IL)-8 and IL-10, have not been investigated. In addition, differences in inflammatory cytokines in tears according to the LDOD subtype have not been reported. This study aimed to quantitatively compare inflammatory cytokines in tears from patients with LDOD and investigate tear-cytokine differences among different LDOD subtypes. Methods : Tear samples were collected from both eyes of 30 patients with unilateral LDOD five patients with prelacrimal obstruction, five with acute dacryocystitis and 20 with chronic dacryocystitis. The contralateral eyes were used as controls. IFN-α2a, IFN-β, IFN-γ, IL-17A, IL-6, IL-8, tumour necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF)-A, induced protein-10 (IP-10) and monocyte chemotactic protein-1 (MCP-1) were quantified in all samples. Results : The expression of eight cytokines (except for IP-10 and MCP-1) were significantly increased in the affected eyes compared with those in the control eyes. The levels of nine inflammatory cytokines (except for IP-10) in the affected eyes of patients with chronic dacryocystitis were higher than those in the affected eyes of patients with prelacrimal obstruction. In addition, patients with chronic dacryocystitis presented significantly higher IFN-γ level than those with prelacrimal obstruction or acute dacryocystitis. Interpretation & conclusions : Specific pro-inflammatory cytokines were increased in tears of patients with LDOD compared with those in the controls. The specific cytokine profiles observed in the tears of individuals with different LDOD subtypes may be associated with the unique aetiopathogenesis of these conditions.

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Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO)

Ali

2023

Progress in Retinal and Eye Research

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Tear protein analysis in patients with primary acquired nasolacrimal duct obstruction treated with lacrimal passage intubation

Cited by 3 publications

References 29 publications

The Role of Systemic Inflammation in Acquired Nasolacrimal Duct Obstruction

The Role of Systemic Inflammation in Acquired Nasolacrimal Duct Obstruction

Detection & analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO)

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