Tebamin — A Derivative of p‐Aminosalicylic Acid: Blood Levels, Absorption and Excretion following Oral Administration.

Frederiksen, E; Jensen, Karin; Mørch, P.; Tybring, L.

doi:10.1111/j.1600-0773.1957.tb01142.x

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…During the 1940s and 1950s, the company maintained a broad portfolio of products of which several were generics (Loldrup, 2014) 2 . Examples include anesthetics (e.g., Citodan 1939-1956, Leostesin 1954-1988, diuretics (e.g., Diuregan 1929-1957, Diural 1937-1945, Rontyl 1958-1996 and hormones (e.g., Delcortol 1957-1996, Heparin from 1940, Solvisat 1957-1976, Testex 1937-1973 in addition to antibiotics. The company also worked on several smaller development projects and product categories.…”

Section: Overview Of Leo Pharma's Research and Product Portfoliomentioning

confidence: 99%

“…Hydrazides and PAS derivatives were of particular interest 16 . A PAS-derivative, p-aminosalicylic acid phenyl ester ("Tebamin") was developed with a less irritating effect on patients than PAS and therefore suitable for the long duration of chemotherapeutic treatment of tuberculosis (Frederiksen et al, 1957;Tørning et al, 1958;Kingston, 2000;Greenwood, 2008;Jain et al, 2008). This compound was on the market from 1955 and up to 1973 and constituted the most successful outcome of LEOs work on anti-tuberculosis compounds (Jensen, 1971;Loldrup, 2014) 17 .…”

Section: Work At Leo On Synthetic and Semisynthetic Antibiotics 1940-mentioning

confidence: 99%

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The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player

Leisner

2020

Front. Microbiol.

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The 1940s and 1950s witnessed a diverse search for not just natural product antibiotics but also for synthetic and semisynthetic compounds. This review revisits this epoch, using the research by a Danish pharmaceutical company, LEO Pharma, as an example. LEO adopted a strategy searching for synthetic antibiotics toward specific bacterial pathogens, in particular Mycobacterium tuberculosis, leading to the discovery of a new derivative of a known drug. Work on penicillin during and after WWII lead to the development of associated salts/esters and a search for new natural product antibiotics. This led initially to no new, marketable compounds, but concluded with the serendipitous discovery of fusidic acid, an antibiotic used to treat infections by Staphylococcus aureus, in 1960. The discovery process included contemporary approaches such as open innovation; targeting specific pathogens and/or specific organs in the patient; examining the effects of antimicrobial compounds on bacterial virulence as well as on antibioticresistant variants, and searching for antibiotic producers among microorganisms not previously well explored. These activities were promoted by the collaboration with a renowned Danish clinical microbiologist, K. A. Jensen, as well as company expertise in fermentation technologies, chemical synthesis and purification of bioactive compounds from organic materials.

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Section: Overview Of Leo Pharma's Research and Product Portfoliomentioning

confidence: 99%

Section: Work At Leo On Synthetic and Semisynthetic Antibiotics 1940-mentioning

confidence: 99%

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player

Leisner

2020

Front. Microbiol.

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Para-aminosalicylic-acid (PAS) concentrations in the serum during treatment with various PAS preparations

Citron

Kuper

1959

Tubercle

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Blood concentrations of pas produced by a mixture of pas and the phenyl ester of pas

Morris

1963

Tubercle

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Tebamin — A Derivative of p‐Aminosalicylic Acid: Blood Levels, Absorption and Excretion following Oral Administration.

Cited by 5 publications

References 6 publications

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player

Para-aminosalicylic-acid (PAS) concentrations in the serum during treatment with various PAS preparations

Blood concentrations of pas produced by a mixture of pas and the phenyl ester of pas

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