Technegas - a new ventilation agent for lung scanning

Quantitative analysis of pulmonary emphysema: three-dimensional fractal analysis of single-photon emission computed tomography images obtained with a carbon particle radioaerosol.

“…Recently,ultrafine @Tc-carbon particles (Technegas; Daiichi Radioisotope, Tokyo,Ja pan) have been usedfor ventilation studiesof the lung [7†"12]. Burch et al [7] reported that Technegas has particles with a considerably small size, and these particles can reach the peripheral parts of the lung [7†"12]. Technegas single-photon emission computed tomography (SPEfT) images show peripheral irregularity in mild emphysemaand further hot spot for mation and regional defects in severe emphy valuesof 55â€"70% haddiagnoses of suspected pul monaryemphysema(fivemen and two women;age range, 33â€"77 years; mean age, 69 years: four smok ersandthreenonsmokers).…”

Quantification and optimisation of lung ventilation SPECT images

“…Common for ventilation examinations is to use Technegas (Burch et al, 1986) which is 99m Tc labelled carbon filled nano-particles. The gas is produced using the Technegas Generator (Tetley Manufacturing Ltd., Sydney, Australia) by adding 99m Tc to the graphite crucible and thereafter vaporise it at 2500° C in an 100% argon atmosphere.…”

“…The gas is inhaled (left image in Figure 3). Burch et al (Burch et al, 1986) reported that the diameter of the particles is 5 nm. However, more recently Harris and Harris have suggested that the diameter is between 10 and 100 nm (Harris and Harris, 2001).…”

Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development

“…It should be noted that if the lungs are to be considered for the systemic delivery, a high percentage of the dose must be delivered to the lungs and the site of deposition should be as peripheral as possible (Colthorpe et al., 1992). An approach to improve the pulmonary delivery of drugs would be to produce much smaller drug particles, as they offer high penetration and deposition of the aerosol (Burch et al, 1986). Nanocarrier systems in pulmonary drug delivery have the potential to achieve relatively uniform distribution of drug dose among the alveoli.…”