Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease

Lantto, Eila; Järvi, Kari; Krekelä, Iikka; Lantto, Tuomo; Taavitsainen, M.; Vedenkangas, Heikki; Vorne, M

doi:10.1007/bf00178302

Cited by 54 publications

(17 citation statements)

References 11 publications

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“…This is in agreement with the findings in a large series of children in whom no false-positive uptakes were observed in the terminal ileum. 32 Nonspecific bowel activity, unrelated to inflammatory bowel disease, has in other studies been observed in the small bowel and proximal colon as early as 30 minutes after injection of technetium-99m exametazime-labeled cells 33 and been found in about 15% of subjects within the first hour. 29,34 In other series, such activity has first been seen on 2-hour images in 7% or on 3-4-hour images in 5%-28% of examinations 31,[35][36][37] or to occur only later than 3 hours.…”

Section: Discussionmentioning

confidence: 97%

Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohnʼs disease

Almér

Granérus²,

Ström

et al. 2007

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 97%

Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohnʼs disease

Almér

Granérus²,

Ström

et al. 2007

Inflammatory Bowel Diseases

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“…Compared with radiology and/or colonoscopy, scintigraphy is better able to detect disease extent [3]. On the other hand, non-specific bowel activity may cause false positive results [9]. Nonspecific intestinal uptake of 18 F-FDG is also a frequent finding on PET imaging of the abdomen.…”

Section: Discussionmentioning

confidence: 98%

18F-FDG positron emission tomography in the early diagnosis of enterocolitis: preliminary results

Kresnik

Mikosch

et al. 2002

Eur J Nucl Med

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Collagenous and eosinophilic colitis are rare diseases characterised by chronic watery diarrhoea. Radiographic evaluation of the gastrointestinal tract and colonoscopy are usually non-diagnostic since as many as one-third of patients will have minor abnormalities. To date a few investigators have reported increased fluorine-18 fluorodeoxyglucose ((18)F-FDG) uptake on positron emission tomography (PET) in patients with acute enterocolitis, but there have been no reports on the use of (18)F-FDG PET for the diagnosis of collagenous or eosinophilic colitis in an early clinical stage. The aim of this preliminary study was to evaluate the usefulness of (18)F-FDG PET in the early diagnosis of patients with colitis. We investigated five women (mean age 61.2+/-12.1 years) who had been diagnosed as having colitis in an early clinical stage. In all but one of the patients, the diagnosis of colitis was based on biopsy. Magnetic resonance colonography, ultrasonography and colonoscopy were performed in all but one of the patients. Two women were identified as having collagenous colitis in an early clinical stage. Another two patients had eosinophilic colitis. The morphological imaging methods, magnetic resonance colonography and ultrasonography, yielded no suspicious findings, and the results of colonoscopy similarly showed no abnormalities. One patient had colitis due to bacterial infection. In all patients (18)F-FDG PET showed a pathological increase in tracer uptake in the large bowel, suggestive of colitis. In four of the five patients, colitis was confirmed by histology, and in one, by bacterial analysis. (18)F-FDG PET was able to detect colitis in an early clinical stage, when morphological imaging methods and colonoscopy were non-diagnostic. The early performance of (18)F-FDG PET imaging in patients with possible colitis is encouraging.

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“…Labeling granulocytes selectively using tecnetium-99 with hexamethyl-propylenamine oxime (HM-PAO) has been used with single-photon emission CT scanning for the study of intestinal inflammatory disease [66]. Its utility has also been proved in patients with EG, being more accurate than biopsy by endoscopy (Fig.…”

Section: Laboratory and Radiology Studiesmentioning

confidence: 99%

Eosinophilic Gastroenteritis: A Review

et al. 2007

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Eosinophilic gastroenteritis is a rare benign disease characterized by tissue eosinophilic infiltration that may involve several digestive tract layers. Also known as allergic, or eosinophilic allergic, gastroenteropathy, it usually involves the stomach and small intestine: rarely the colon. It may or may not be accompanied by higher counts of eosinophils in the peripheral blood. The main clinical manifestations depend on the site affected. It has been classified according to clinical and pathological features, and the symptoms depend on the patient's immunological response to several cytokines released by eosinophils. Because of lack of understanding of the etiology and triggering factors, treatment is based mainly on corticosteroids; although other drugs acting on the immune system have been tested, the results are not always satisfactory. This review focuses on the epidemiology, pathophysiology, clinical features, and treatment of this hitherto under-diagnosed disease.

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Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease

Cited by 54 publications

References 11 publications

Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohnʼs disease

Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohnʼs disease

18F-FDG positron emission tomography in the early diagnosis of enterocolitis: preliminary results

Eosinophilic Gastroenteritis: A Review

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