Technetium‐99m‐labelled HL91 and technetium‐99m‐labelled MIBI SPECT imaging for the detection of ischaemic viable myocardium: a preliminary study

Liu, Min; Ma, Zhanhong; Guo, Xiaojuan; Zhu, Jianguo; Su, Jun

doi:10.1111/j.1475-097x.2011.01050.x

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Complete cardiomyocyte function is excitatory, conductive and contractile, and good blood perfusion and myocardial cell metabolic activity are necessary to maintain its normal physiological activities ( 17 , 18 ). It is generally thought that necrotic and scarred myocardium is a type of myocardial damage, which cannot be reversed.…”

Section: Discussionmentioning

confidence: 99%

Low‑dose dobutamine stress myocardial contrast echocardiography for the evaluation of myocardial microcirculation and prediction of overall cardiac function recovery

et al. 2020

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The study aimed to investigate the role of low-dose dobutamine stress myocardial contrast echocardiography (MCE) in evaluating myocardial local microcirculation and predicting cardiac function recovery in patients with myocardial infarction. A total of 50 patients with acute myocardial infarction (AMI) were enrolled in the present study. Positron emission tomography was used as a gold standard to determine viable/non-viable myocardial segments in infarcted myocardial region. MCE and dobutamine stress MCE were carried out 72 h after PCI. MCE was carried out again to evaluate myocardial condition at 6 months after PCI. As compared with normal myocardial segments, resting MCE revealed a significant decrease of the values of A (the peak intensity of the time-perfusion intensity curve, reflecting the myocardial blood volume), β (the slope of the curve, reflecting the myocardial blood flow (MBF) velocity) and A x β (reflecting MBF) of viable and non-viable myocardial segments. After being challenged by dobutamine, the values of A, β and A x β of normal coronary blood supply areas were significantly increased; while the segments A and A x β of viable myocardium were markedly decreased. Patients were further divided into two groups based on the changes in the contrast-enhanced index (CSI) following dobutamine loading. In the dobutamine stress echocardiography-positive group (the CSI increased or decreased by >0.2), the left ventricular ejection fraction was significantly increased and pro-B-type natriuretic peptide significantly decreased at 6 months following intervention. Low-dose dobutamine stress MCE was indicated to be an effective method to evaluate myocardial microcirculation perfusion in patients with AMI following PCI. In addition, CSI, as a simple semi-quantitative index, may predict left ventricular function in patients with AMI.

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Section: Discussionmentioning

confidence: 99%

Low‑dose dobutamine stress myocardial contrast echocardiography for the evaluation of myocardial microcirculation and prediction of overall cardiac function recovery

et al. 2020

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“…Another recent approach with Tc-99m compounds has included Tc-99m labeled HL91, which is introduced as an alternative application for the viability assessment. Viability was defined as reduced Tc-99m MIBI uptake and increased Tc-99m HL91 uptake; a 'mismatch' pattern, especially in the three hour images, which showed high diagnostic accuracy [ 16 ] .…”

Section: Discussionmentioning

confidence: 99%

Twenty four hour imaging delay improves viability detection by Tl-201 myocardial perfusion scintigraphy

Koç¹,

Balcı²,

Dağlı³

2013

Revista Brasileira De Cirurgia Cardiovascular

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Objective Since twenty-four-hour imaging by Tl-201 myocardial perfusion scintigraphy has been introduced as an effective additional procedure, the aim of this study was to compare this method's result with only rest redistribution procedure in the diagnosis of myocardial viability. Methods Thirty patients (Seven female, 23 male; mean: 59.8 ± 10.7, 55.8-63.8 years old) with diagnosis of coronary artery disease were involved in this study. All patients had anamnesis of previous myocardial infarction and/or total occlusion of any main artery in the coronary angiography. Myocardial perfusion scintigraphy with Tl-201 with rest four hour (early) redistribution and 24 hour delayed redistribution protocol were performed to all of the patients. The images were evaluated according to 17 segment basis by an experienced nuclear medicine physician and improvement of a segment by visual interpretation was considered as viable myocardial tissue. Results Viability was found at 52 segments in the early redistribution images and additional 18 segments in the 24 hour delayed redistribution images on segment basis in the evaluation of 510 segments of 30 patients. On per patient basis, among the 26 patients who had viable tissue, 14 (54%) had additional improvement in 24 hour delayed images. Three (12%) patients had viable tissue in only 24 hour delayed images. Conclusion Delayed imaging in Tl-201 MPS is a necessary application for the evaluation of viable tissue according to considerable number of patients with additional improvement in 24 hour images in our study, which is restricted to the patients with myocardial infarct.

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“Hot spots” in the brain

Kannan¹,

Johnston

2012

Critical Care Medicine

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Technetium‐99m‐labelled HL91 and technetium‐99m‐labelled MIBI SPECT imaging for the detection of ischaemic viable myocardium: a preliminary study

Abstract: Functional SPECT imaging with (99m)Tc-HL91 and (99m)Tc-MIBI can be used to detect the seriously ischaemic but viable myocardium with a mismatched uptake character. The uptake of (99m)Tc-HL91 in the viable myocardium reached a stable level at 3-4 h after injection.

Cited by 4 publications

References 31 publications

Low‑dose dobutamine stress myocardial contrast echocardiography for the evaluation of myocardial microcirculation and prediction of overall cardiac function recovery

Low‑dose dobutamine stress myocardial contrast echocardiography for the evaluation of myocardial microcirculation and prediction of overall cardiac function recovery

Twenty four hour imaging delay improves viability detection by Tl-201 myocardial perfusion scintigraphy

“Hot spots” in the brain

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