Technetium 99m‐MDP Scintigraphy of Patients Undergoing Implant Prosthetic Procedures: A Follow‐Up Study

Abstract

The clinical evaluation of peri-implant tissue is mainly based on x-rays. In recent years, radioisotope scintigraphy using Tc-99m-MDP (technetium-99m-methylene diphosphonate) proved to be a useful and reliable clinical method for measuring increased metabolic activity at specific sites of the skeletal tissue. Twenty-six (26) patients (26 to 75 years) who were diagnosed for implant prosthetic treatment modality were randomly chosen to participate in this study. Each patient was injected with 20 mCi of Tc-99m-MDP was scanned 2 hours later by gamma-camera for isotope uptake levels in the jaws. Each patient was scanned 1 to 4 times, starting 2 weeks after implant surgery and up to the 40th week postsurgery. Blade and screw type implants using the non-submerged, one-stage technique were placed. Therefore, the prosthetic reconstruction was initiated 2 weeks after implant surgery. In order to compare the different scans we formulated a relative "bone scan index" (BSI). The results of 62 scans were plotted as BSI against time after implant surgery. A mathematical regression analysis of the BSI was also performed. At the initial stage of 2 to 3 weeks after surgery the BSI is high and then gradually declines. While BSI of the implants in the mandible reaches baseline levels after 12 weeks, the BSI in the maxilla reaches baseline only after 20 weeks. On the other hand, there was no difference in BSI with regard to blade or screw type implant. Here we were able to demonstrate that the process is independent of implant modality and depends on the specific metabolic properties of the jaw.(ABSTRACT TRUNCATED AT 250 WORDS)

Role of single photon emission computerised tomography in evaluating osseointegration of indigenous DRDO implants: An in vivo study

“…[10][11][12][13] The reliability of RFA to predict implant stability and to determine loading time remains questionable. 14 Use of histological and histomorphometric methods 15,16 for the purpose requires sacrifice of the area of interest along with the implant.…”

“…The variations (Table 3) can be attributed to the fact that the process of osseointegration is independent of design and depends on the specific metabolic process of the bone in reaction to the quality of metal used. 10 As all the documented studies have followed strict patient selection protocols to exclude variables influencing the metabolic process of osseointegration/healing and have considered the mean values of osteoblastic activity from a cross-section of patients for their studies, we have no reason to disbelieve our comparative evaluation with other implant systems. It can be summarized that the protocol of sequential SPECT imaging demonstrated along with the calculation of osteoblastic activity can provide an excellent model to study the progress of various graft/implants used for various reconstructions.…”

Scintigraphic Evaluation of Osseointegrative Response around Calcium Phosphate-Coated Titanium Implants in Tibia Bone: Effect of Platelet-Rich Plasma on Bone Healing in Dogs

“…Bone scintigraphy has frequently been recommended for noninvasive monitoring of bone healing and bone metabolism that cannot be monitored by radiography. Scintigraphy using 99m Tc-MDP is also a useful and reliable clinical method for measuring increased metabolic activity in peri-implant bone tissue [18]. However, these results were not considered evidence of increased bone uptake due to postoperative infection and metastatic bone neoplasia [19].…”

Biomechanical dental implants comparison by means of numerical models and nuclear medicine

“…The technique consists in imaging the uptake of bone-seeking radiopharmaceuticals, in the mineral component of bone as well as in the organic matrix; in particular, technetium-99m labelled diphosphonates are used [9]. Several recent medical reports have focused their attention on the possible application of skeletal scintigraphy imaging to odontostomatology [10][11][12][13][14][15][16].…”