Technical Advances in Current PET and Hybrid Imaging Systems

Lee, Jae Sung

doi:10.2174/1876388x01002010192

Cited by 25 publications

(21 citation statements)

References 84 publications

(115 reference statements)

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“…In a previous study, we showed a 1-ns coincidence timing resolution using LYSO/SiPM detector pairs (11). Moreover, there is increasing evidence that SiPM is feasible for time-of-flight measurement (8,28). A coincidence timing resolution of 240 ps can be achieved with LYSO and multipixel photon counter (MPPC, the SiPM provided by Hamamatsu Photonics) couplings under optimal conditions of bias voltage and temperature (12).…”

Section: Discussionmentioning

confidence: 94%

Development of Small-Animal PET Prototype Using Silicon Photomultiplier (SiPM): Initial Results of Phantom and Animal Imaging Studies

Kwon¹,

Lee²,

Yoon³

et al. 2011

J Nucl Med

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Silicon photomultiplier (SiPM; also called a Geiger-mode avalanche photodiode) is a promising semiconductor photosensor in PET and PET/MRI because it is intrinsically MRI-compatible and has internal gain and timing properties comparable to those of a photomultiplier tube. In this study, we have developed a smallanimal PET system using SiPMs and lutetium gadolinium oxyorthosilicate (LGSO) crystals and performed physical evaluation and animal imaging studies to show the feasibility of this system. Methods: The SiPM PET system consists of 8 detectors, each of which comprises 2 · 6 SiPMs and 4 · 13 LGSO crystals. Each crystal has dimensions of 1.5 · 1.5 · 7 mm. The crystal face-toface diameter and axial field of view are 6.0 cm and 6.5 mm, respectively. Bias voltage is applied to each SiPM using a finely controlled voltage supply because the gain of the SiPM strongly depends on the supply voltage. The physical characteristics were studied by measuring energy resolution, sensitivity, and spatial resolution. Various mouse and rat images were obtained to study the feasibility of the SiPM PET system in in vivo animal studies. Reconstructed PET images using a maximum-likelihood expectation maximization algorithm were coregistered with animal CT images. Results: All individual LGSO crystals within the detectors were clearly distinguishable in flood images obtained by irradiating the detector using a 22 Na point source. The energy resolution for individual crystals was 25.8% 6 2.6% on average for 511-keV photopeaks. The spatial resolution measured with the 22 Na point source in a warm background was 1.0 mm (2 mm off-center) and 1.4 mm (16 mm off-center) when the maximum-likelihood expectation maximization algorithm was applied. A myocardial 18 F-FDG study in mice and a skeletal 18 F study in rats demonstrated the fine spatial resolution of the scanner. The feasibility of the SiPM PET system was also confirmed in the tumor images of mice using 18 F-FDG and 68 Ga-RGD and in the brain images of rats using 18 F-FDG. Conclusion: These results indicate that it is possible to develop a PET system using a promising semiconductor photosensor, which yielded reasonable PET performance in phantom and animal studies.

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Section: Discussionmentioning

confidence: 94%

Development of Small-Animal PET Prototype Using Silicon Photomultiplier (SiPM): Initial Results of Phantom and Animal Imaging Studies

Kwon¹,

Lee²,

Yoon³

et al. 2011

J Nucl Med

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“…The radial distribution of the detectors can be varied. For human whole body and brain imaging PET diameters are approximately 70-87 cm and 40-50 cm, respectively (Lee , J.S., 2010;Moses, W.W. et al, 1997). The further the detectors are placed apart the more likely the gamma signal will deviate from 180 o C (i.e.…”

Section: Human Pet Camerasmentioning

confidence: 99%

Production and Selection of Metal PET Radioisotopes for Molecular Imaging

Smith¹,

Jones²,

Holmes³

2011

Radioisotopes - Applications in Bio-Medical Science

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“…For this purpose, PET imaging techniques [4,5,6,7] for measuring concentrations of positron-emitting radioisotope within the tissue of living subjects have been developed by researchers from diverse disciplines for the last decade. Since the first introduction of PET to medical imaging applications in the late 1960's, it has already grown into a well-researched, highly evolved field [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

RECONSTRUCTION OF MaxEnt IMAGES FROM PET CAMERA

Üstündağ¹

2017

RAD Conference Proceedings

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Abstract. We study here one of the imaging techniques, used in nuclear medicine, called a Positron Emission Tomographic (PET) imaging that provides information about many biological processes that are essential to the functioning of the organ that is being visualized. Our emphasis is given to applications of the maximum entropy image reconstruction method called "Cambridge MaxEnt Package" (CMEP) for recovering images of the human brain from data obtained by PET camera. Computer simulations demonstrate its usefulness.

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Technical Advances in Current PET and Hybrid Imaging Systems

Cited by 25 publications

References 84 publications

Development of Small-Animal PET Prototype Using Silicon Photomultiplier (SiPM): Initial Results of Phantom and Animal Imaging Studies

Development of Small-Animal PET Prototype Using Silicon Photomultiplier (SiPM): Initial Results of Phantom and Animal Imaging Studies

Production and Selection of Metal PET Radioisotopes for Molecular Imaging

RECONSTRUCTION OF MaxEnt IMAGES FROM PET CAMERA

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