Humidification dehumidification desalination (HDH) is a promising technology for small-scale water production applications. There are several embodiments of this technology which have been investigated by researchers around the world. However, from a previous literature review [1], we have found no study which carried out a detailed thermodynamic analysis in order to improve and/or optimize the system performance. In this paper, we analyze the thermodynamic performance of various HDH cycles by way of a theoretical cycle analysis. In addition, we propose novel high-performance variations on those cycles. These high-performance cycles include multi-extraction, multi-pressure and thermal vapor compression cycles. It is predicted that the systems based on these novel cycles will have gained-output ratio in excess of 7 and will outperform existing HDH systems.