Studies from around the world show that engines using biofuel, LPG, and CNG emit fewer pollutants than those using conventional fuels. Experimental research has focused on a rapid compression and expansion machine (RCEM) that resembles a compression ignition (CI) engine. It uses dual direct injection fuel, diesel and propane (DP), with propane injection timing varying from 0 to 40 before top dead center (BTDC) and diesel injection timing remaining at 10 BTDC. The compression ratio was changed at points 17 and 19 by adjusting the RCEM connecting rod. A converge simulation program was used to run the simulation model, which was used to examine how the fire and inflow inside the chamber developed. The ANN method was used to predict pressure, temperature, power, TKE, and ITE data output based on propane energy fraction, compression ratio, and SOI of propane as input data parameters. It was noticed that the ANN prediction on experimental data has a higher accuracy compared to the simulation prediction. The R and MSE values were used to identify the accuracy of the prediction on output parameter data. ANN generalization capability is comparatively high when trained with large enough databases. The highest accuracy of prediction was produced on TKE, which had an MSE of 0.003715 and R value of 0.99981 from 287900 sample data. This shows that the ANN model is quite accurate in forecasting output experimental data.