Background: Diseases of the gallbladder are relatively common, and the most common pathology ischolelithiasis, affecting 10 -15 % of the population. Aim and objectives: To study the detection rate of gallbladder diseases by Endoscopic Ultrasound (EUS) in comparison to Trans abdominal Ultrasound (TAUS). Patient and methods: This was a prospective cross sectional study conducted on 100 patients fulfilling the inclusion criteria in Maadi Military Hospital. All the data were collected after ethical approval. Results: According to indication of EUS there were 19 (19%) patients had pancreatic mass, 55 (55%) patients had abdominal pain, 8 (8%) patients had pancreatitis, 12 (12%) patients had obstructive jaundice, 4 (4%) patients had pancreatic cyst, and 2 (2%) patients had a follow up cancer. Our results showed that there was a significant relationship between EUS and trans-abdominal US findings (P value <0.001). Also, our results showed that there was a significant moderate agreement between EUS and trans-abdominal US findings (k= 0.491, P value <0.001). Conclusion: Endoscopic Ultrasound (EUS) is a valuable tool for detecting gallbladder diseases; it has potential superiority over TAUS in diagnosing gallbladder diseases, especially when a detailed assessment is crucial.