Technical Aspects of Gallbladder Cancer Surgery

Qadan, Motaz; Kingham, T. Peter

doi:10.1016/j.suc.2015.12.007

Cited by 29 publications

(17 citation statements)

References 72 publications

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“…Gallbladder carcinoma (GBC) is a rare malignancy in the Western world. 17 As a result, it is an understudied disease and data pertaining to long-term outcomes after resection of GBC remain scarce. In fact, most studies reporting on outcomes after surgical management of GBC have focused largely on overall HPB survival rather than recurrence.…”

Section: Discussionmentioning

confidence: 99%

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium

Margonis

Gani

Buettner

et al. 2016

HPB

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Section: Discussionmentioning

confidence: 99%

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium

Margonis

Gani

Buettner

et al. 2016

HPB

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“…While these lesions can extend to involve the hepaticoduodenal ligament, malignant lesions arising in the body and Hartmann pouch of gallbladder are likely to involve the hepatic duct earlier in the progression of the disease compared with more distal lesions. Extension of the disease to the porta hepatis of the liver can decrease, if not preclude altogether, the chance of radical intent resection . Despite this, there is no such distinction in the American Joint Committee on Cancer (AJCC) staging of GBC for T3 disease based on the site of the lesion…”

Section: Introductionmentioning

confidence: 99%

“…Extension of the disease to the porta hepatis of the liver can decrease, if not preclude altogether, the chance of radical intent resection. 3 Despite this, there is no such distinction in the American Joint Committee on Cancer (AJCC) staging of GBC for T3 disease based on the site of the lesion. 4 Preoperative jaundice is considered by many surgeons to be a relative contraindication to radical GBC resection.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of surgical resection of gallbladder cancer in patients presenting with jaundice: A systematic review and meta‐analysis

Dasari

Ionescu

Pawlik

et al. 2018

Journal of Surgical Oncology

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Introduction Preoperative jaundice is considered a relative contraindication to radical gallbladder cancer (GBC) resection due to poor prognosis and high postoperative morbidity. Recent reports have indicated that aggressive surgery may improve long‐term survival for patients with advanced GBC who present with obstructive jaundice. The current systematic review and meta‐analysis aimed to compare postoperative outcomes among jaundiced and non‐jaundiced patients with resectable GBC. Methods An electronic search was performed using several Medical Subject Headings terms: cholecyst, gallbladder, tumor, cancer, carcinoma, adenocarcinoma, neoplasia, neoplasm, jaundice, and icterus. Overall survival after surgery was the primary outcome; resectability and postoperative morbidity were the secondary outcomes. Results Overall survival was shorter among patients who presented with jaundice (Hazard ratio [HR]: 2.21, 95% confidence interval [CI], 1.64‐2.97; P < 0.001). Patients with jaundice were less likely to have resectable disease (odds ratio: 0.27, 95% CI, 0.17‐0.43; P < 0.001). The jaundice group had higher odds of postoperative morbidity, bile‐leak, and posthepatectomy failure versus the non‐jaundiced control group. Conclusions Radical surgery for GBC resection for patients presenting with obstructive jaundice was associated with reduced overall survival and increased postoperative morbidity. Jaundiced patients with advanced GBC should be considered for surgical resection but need careful evaluation and counseling before undertaking extensive surgical resection.

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“…There is consensus that simple cholecystectomy or LC is adequate for pT1a tumours. Tumours at pT2 and higher stages require additional radical surgery, such as a hepatic S4a + S5 resection and hepatic pedunculated lymphadenectomy [27,29,30].…”

Section: Discussionmentioning

confidence: 99%

Relationship between clinical and histopathological features of patients undergoing cholecystectomy

Akbulut

Yağmur

Sakarya

et al. 2020

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Introduction: Cholelithiasis is most common disease of the gallbladder and cholecystectomy is the one of the most performed surgical procedure worldwide. Aim: To assess the relationship between the demographic, biochemical, and histopathological variables of patients who underwent cholecystectomy. Material and methods: Demographic, biochemical, and histopathological data of 5077 patients undergoing cholecystectomy were compared in terms of two different aspects: open cholecystectomy (OC group; n = 2090) versus laparoscopic cholecystectomy (LC group; n = 2987), and an elective group (n = 4814) versus an emergency group (n = 263). Results: A total of 5077 patients aged between 13 and 97 years were included in the study. Aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT) levels, mean platelet volume, and prevalence of acute/chronic cholecystitis were significantly higher in the LC group than in the OC group. On the other hand, age, direct bilirubin level, thrombocyte count, and prevalence of gallbladder cancer/gangrenous cholecystitis were significantly higher in the OC group than in the LC group. Levels of AST, ALT, white blood cells, neutrophils, and some prevalence of acute/chronic active cholecystitis were higher in the emergency group than in the elective group. On the other hand, the lymphocyte count and prevalence of chronic cholecystitis/hyperplastic polyps were higher in the elective group than in the emergency group. Histopathological analysis identified 32 patients with malignant gallbladder cancer as follows: adenocarcinoma (n = 21), mucinous adenocarcinoma (n = 3), papillary adenocarcinoma (n = 3), adenosquamous carcinoma (n = 1), clear cell adenocarcinoma (n = 2), squamous carcinoma (n = 1), and hepatocellular carcinoma metastasis (n = 1). Conclusions: Even when the appearance of gallbladder specimens is normal, histopathological assessment allows for early diagnosis of many unusual findings such as gallbladder cancer.

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Technical Aspects of Gallbladder Cancer Surgery

Cited by 29 publications

References 72 publications

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium

Outcomes of surgical resection of gallbladder cancer in patients presenting with jaundice: A systematic review and meta‐analysis

Relationship between clinical and histopathological features of patients undergoing cholecystectomy

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