Technical aspects of intraluminal pH-metry in man: current status and recommendations.

Emde, C; Garner, A.; Blum, A. L.

doi:10.1136/gut.28.9.1177

Cited by 167 publications

(59 citation statements)

References 24 publications

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“…Sampling from the duodenal bulb using a conventional method of probe positioning is unreliable because of migration of duodenal pH electrode. Electrode displacement can occur after food intake, changes in body position, and alterations in gastrointestinal motility (23). In addition, as there is a sharp pH gradient along the length of the duodenal bulb, consistency in the position of the recording electrodes is essential (24).…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study on Duodenal Acid Exposure and Its Relationship to Symptoms in Functional Dyspepsia with Prominent Nausea

et al. 2004

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BACKGROUND: Duodenal hypersensitivity to acid and decreased duodenal clearance of exogenous acid have been reported in functional dyspepsia (FD). However, the relevance of these abnormalities to spontaneous duodenal acid exposure and dyspeptic symptoms in FD is unknown. AIMS:To determine spontaneous duodenal acid exposure and its relationship with symptoms, duodenal sensitivity to acid, and the effects of a 5-HT 3 receptor antagonist on duodenal responses to acid in FD. METHODS:Eleven FD patients with prominent nausea and 11 healthy controls underwent 24-h ambulatory duodenal pH monitoring with assessment of dyspeptic symptoms. On the next day, duodenal bolus infusions of 5 ml of acid and normal saline were given in a randomized double-blind manner and repeated after ondansetron or a placebo. RESULTS:Nighttime duodenal acid exposure was similar, but FD patients had lower duodenal pH and higher duodenal % time (pH < 4) than controls during the daytime and in the second postprandial 2 h (p < 0.05). Seven patients (64%) with duodenal acid exposure above the normal range had higher severity scores for several dyspeptic symptoms including nausea. However, the symptom severity was poorly or weakly correlated to duodenal pH, and brief duodenal acid infusion did not affect any symptoms. Duodenal responses to exogenous acid were unaffected by 5-HT 3 receptor antagonism.CONCLUSIONS: Spontaneous duodenal acid exposure is increased in a subset of FD patients with prominent nausea, and this is associated with more severe dyspeptic symptoms. However, a direct relationship between duodenal acid exposure and symptom severity is lacking.

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Section: Discussionmentioning

confidence: 99%

A Pilot Study on Duodenal Acid Exposure and Its Relationship to Symptoms in Functional Dyspepsia with Prominent Nausea

et al. 2004

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“…At the time of the endoscopy a biopsy of the antrum was taken for histological examination. All subjects received Midazolam (Hypnovel) 4 The gastric biopsies were examined in a single blind fashion using haematoxylin and cosin stain. Campylobacter-like organisms were identified by the fast cresyl violet stain.…”

Section: Endoscopic Procldurementioning

confidence: 99%

Comparison of gastric body and antral pH: a 24 hour ambulatory study in healthy volunteers.

McLauchlan

Fullarton

Crean

et al. 1989

Gut

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SUMMARY Simultaneous ambulatory records of gastric antral and body pH were made over 24 hours in nine healthy volunteers by means of endoscopically positioned and anchored glass electrodes. Intragastric pH was temporarily raised after the endoscopy with the median pH value 30 minutes after the procedure being 3.9 (range 1 5-70) for the antrum and 4.1 (range 1 5-70) for the body. Daytime pH (median pH value between 1200 h and 2300 h) was lower in the antrum (median=1.9, range 16-2.6) than in the body (median=2.7, range 1.8-45) (p<0O05) and this was because of the rise in pH on eating being less marked in the antrum than in the body. The median peak pH recorded during the evening meal was only 4.1 (range 24-642) in the antrum compared with 6.3 (range 4.4-6.7) in the body (p<001). Preprandial pH (median value over the hour prior to the evening meal) was similar in the antrum (median= 1 9, range 1 2-25) and body (median= 1 9, range 1.3-28). Night-time pH (median pH value between 2300 h and 0500 h) in six subjects remained low and was similar in the antrum (median= 14, range 12-1.7) and body (median=13, range 11-1-7). In two subjects, however, there were episodes of raised night-time pH which were more marked in the antrum than in the body. Antral biopsies showed gastritis in four of the nine normal volunteers, which in three was associated with the presence of campylobacter-like organisms. This study shows the significant regional variations in day and night-time intragastric pH.Over the past decade there has been a dramatic increase in the use of ambulatory pH monitoring of the upper gastrointestinal tract (GIT) for research purposes and as an aid to diagnosis. Previously, most studies of intragastric pH depended on the analysis of aspirated gastric juice and had several shortcomings. Gastric aspiration may invoke duodenogastric reflux or stimulate acid secretion' and may be difficult after a solid meal or during the night when little juice is present in the stomach.3 The use of in situ pH electrodes overcomes these problems and also allows the monitoring of pH in specific regions of the stomach rather than just giving a mean intragastric value. Because of the problems of maintaining the position of electrodes within the stomach, little is

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“…Direct measuring of acidity in gastrointestinal tract [11] has a number of disadvantages: it requires substantial time and material costs; measuring can be accomplished only in several points in certain moments, predicting is complicated, and an examined individual can suffer from unpleasant sensations. Besides, penetration of measuring devices into a human body can skew research results.…”

mentioning

confidence: 99%

Numerical modeling of acidity distribution in antroduodenum aimed at identifying anomalous zones at consuming drinks with different pH level

Kamaltdinov¹,

Zaitseva²,

Шур³

2017

Health Risk Analysis

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Technical aspects of intraluminal pH-metry in man: current status and recommendations.

Cited by 167 publications

References 24 publications

A Pilot Study on Duodenal Acid Exposure and Its Relationship to Symptoms in Functional Dyspepsia with Prominent Nausea

A Pilot Study on Duodenal Acid Exposure and Its Relationship to Symptoms in Functional Dyspepsia with Prominent Nausea

Comparison of gastric body and antral pH: a 24 hour ambulatory study in healthy volunteers.

Numerical modeling of acidity distribution in antroduodenum aimed at identifying anomalous zones at consuming drinks with different pH level

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