Technical basis for using passive sampling as a biomimetic extraction procedure to assess bioavailability and predict toxicity of petroleum substances

Redman, Aaron D.; Butler, Josh D.; Letinski, Daniel J.; Toro, Dominic M. Di; Paumen, Miriam Leόn; Parkerton, Thomas F.

doi:10.1016/j.chemosphere.2018.02.024

Cited by 38 publications

(49 citation statements)

References 32 publications

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“…Concentrations of potential bioaccumulating substances in the streams treated with effluents fortified with kerosene and diesel were significantly higher and ranged between 2 and 3 mmol chemical/L PDMS. Using an acute-to-chronic ratio of 3.8 (Redman et al 2012b), these values are within the range of the acute potential bioaccumulating substance-based thresholds presented by Redman et al (2018). Because these authors also showed that the difference between 30-and 100-mm fiber was limited, it can be concluded that the observed effects were generally in line with expected toxicity based on potential bioaccumulating substance measurements.…”

Section: Discussionsupporting

confidence: 68%

Investigating predictive tools for refinery effluent hazard assessment using stream mesocosms

Cailleaud

Bassères

Gelber

et al. 2019

Enviro Toxic and Chemistry

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Hazard assessment of refinery effluents is challenging because of their compositional complexity. Therefore, a weight‐of‐evidence approach using a combination of tools is often required. Previous research has focused on several predictive tools for sophisticated chemical analyses: biomimetic extraction to quantify the potentially bioaccumulative substances, 2‐dimensional gas chromatography, modeling approaches to link oil composition to toxicity (PETROTOX), and whole‐effluent toxicity assessments using bioassays. The present study investigated the value of these tools by comparing predicted effects to actual effects observed in stream mesocosm toxicity studies with refinery effluents. Three different effluent samples, with and without fortification by neat petroleum substances, were tested in experimental freshwater streams. The results indicate that the biological community shifted at higher exposure levels, consistent with chronic toxicity effects predicted by both modeled toxic units and potentially bioaccumulative substance measurements. The present study has demonstrated the potential of the predictive tools and the robustness of the stream mesocosm design to improve our understanding of the environmental hazards posed by refinery effluents. Environ Toxicol Chem 2019;38:650–659. © 2018 SETAC

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Section: Discussionsupporting

confidence: 68%

Investigating predictive tools for refinery effluent hazard assessment using stream mesocosms

Cailleaud

Bassères

Gelber

et al. 2019

Enviro Toxic and Chemistry

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“…In this context, PAH derivates of, e.g., phenanthrene have been found to induce significantly increased micronuclei rates in permanent cell lines [73], while the parent compound did not [70]. The limited explanation of WAF-induced biological effects by chemical profiling (e.g., via total petroleum hydrocarbon analysis) has already been observed previously [74,75]. In addition, it has to be considered that the WAF concentrations change throughout the exposure, even though absorption is expected to be reduced in the glass-coated well plates used.…”

Section: Comparison Of Different Oil Types and The Influence Of Chemimentioning

confidence: 81%

Combining Different In Vitro Bioassays to Evaluate Genotoxicity of Water-Accommodated Fractions from Petroleum Products

Johann

Gossen

Behnisch

et al. 2020

Toxics

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Genotoxicity assessment is of high relevance for crude and refined petroleum products, since oil compounds are known to cause DNA damage with severe consequences for aquatic biota as demonstrated in long-term monitoring studies. This study aimed at the optimization and evaluation of small-scale higher-throughput assays (Ames fluctuation, micronucleus, Nrf2-CALUX®) covering different mechanistic endpoints as first screening tools for genotoxicity assessment of oils. Cells were exposed to native and chemically dispersed water-accommodated fractions (WAFs) of three oil types varying in their processing degree. Independent of an exogenous metabolic activation system, WAF compounds induced neither base exchange nor frame shift mutations in bacterial strains. However, significantly increased chromosomal aberrations in zebrafish liver (ZF-L) cells were observed. Oxidative stress was indicated for some treatments and was not correlated with observed DNA damage. Application of a chemical dispersant increased the genotoxic potential rather by the increased bioavailability of dissolved and particulate oil compounds. Nonetheless, the dispersant induced a clear oxidative stress response, indicating a relevance for general toxic stress. Results showed that the combination of different in vitro assays is important for a reliable genotoxicity assessment. Especially, the ZF-L capable of active metabolism and DNA repair seems to be a promising model for WAF testing.

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“…The most recurrent argument against using lethal and sublethal fish embryo data is predicated on the small number of reliable datasets that directly compare the FET with the acute and chronic fish toxicity tests, especially data from unknown or variable composition, complex reaction products, and biological materials of limited solubility. As highlighted earlier, Redman et al () showed that zebrafish embryos are of median sensitivity when plotted against other organisms.…”

Section: Discussionmentioning

confidence: 76%

“…(2018) showed that zebrafish embryos are of median sensitivity when plotted against other organisms. When we plotted our data (acute sublethal fish embryo) with chronic toxicity data from Redman et al (2018), we saw a similar pattern of acute zebrafish embryo sublethal effects occurring at a similar BE response as chronic 28-d growth inhibition (EC20) in rainbow trout. A similar response when sublethal acute data are compared with chronic fish data indicates that sublethal effects observed in the zebrafish embryo tests could be predictive of chronic toxicity ( Figure 5; Redman et al 2018).…”

Section: Discussionmentioning

confidence: 77%

Analysis of Sublethal Toxicity in Developing Zebrafish Embryos Exposed to a Range of Petroleum Substances

Hedgpeth

Redman²,

Alyea

et al. 2019

Environ Toxicol Chem

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The Organisation for Economic Co‐operation and Development (OECD) test guideline 236 (fish embryo acute toxicity test; 2013) relies on 4 endpoints to describe exposure‐related effects (coagulation, lack of somite formation, tail‐bud detachment from the yolk sac, and the presence of a heartbeat). Danio rerio (zebrafish) embryos were used to investigate these endpoints along with a number of additional sublethal effects (cardiac dysfunction, pericardial edema, yolk sac edema, tail curvature, hatch success, pericardial edema area, craniofacial malformation, swim bladder development, fin development, and heart rate) following 5‐d exposures to 7 petroleum substances. The substances investigated included 2 crude oils, 3 gas oils, a diluted bitumen, and a petrochemical containing a mixture of branched alcohols. Biomimetic extraction–solid‐phase microextraction (BE–SPME) was used to quantify freely dissolved concentrations of test substances as the exposure metric. The results indicated that the most prevalent effects observed were pericardial and yolk sac edema, tail curvature, and lack of embryo viability. A BE–SPME threshold was determined to characterize sublethal morphological alterations that preceded embryo mortality. Our results aid in the understanding of aquatic hazards of petroleum substances to developing zebrafish beyond traditional OECD test guideline 236 endpoints and show the applicability of BE–SPME as a simple analytical tool that can be used to predict sublethal embryo toxicity. Environ Toxicol Chem 2019;38:1302–1312. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.

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Technical basis for using passive sampling as a biomimetic extraction procedure to assess bioavailability and predict toxicity of petroleum substances

Cited by 38 publications

References 32 publications

Investigating predictive tools for refinery effluent hazard assessment using stream mesocosms

Investigating predictive tools for refinery effluent hazard assessment using stream mesocosms

Combining Different In Vitro Bioassays to Evaluate Genotoxicity of Water-Accommodated Fractions from Petroleum Products

Analysis of Sublethal Toxicity in Developing Zebrafish Embryos Exposed to a Range of Petroleum Substances

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