1997
DOI: 10.1007/s002340050373
|View full text |Cite
|
Sign up to set email alerts
|

Technical considerations on intra-arterial papaverine hydrochloride for cerebral vasospasm

Abstract: Intra-arterial infusion of papaverine hydrochloride for subarachnoid hemorrhage-induced cerebral vasospasm has become an adjunctive endovascular therapy along with cerebral angioplasty. Our knowledge concerning the mechanism of action, method of administration and potential side effects of this therapeutic alternative are reviewed.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
22
0
1

Year Published

1999
1999
2012
2012

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 58 publications
(24 citation statements)
references
References 15 publications
1
22
0
1
Order By: Relevance
“…6,18) High-dose papaverine can form a crystalline precipitate with components of human serum and may cause microembolic-related ischemic events, but this consideration appears to be only relevant to intraarterial papaverine administration. 15) Although we cannot clearly establish a cause-andeffect relationship, we suggest that the clinical and electrophysiological course of this case is striking enough to support the previous report that topical papaverine application can lead to transient facial nerve dysfunction.…”
Section: Discussionsupporting
confidence: 66%
See 3 more Smart Citations
“…6,18) High-dose papaverine can form a crystalline precipitate with components of human serum and may cause microembolic-related ischemic events, but this consideration appears to be only relevant to intraarterial papaverine administration. 15) Although we cannot clearly establish a cause-andeffect relationship, we suggest that the clinical and electrophysiological course of this case is striking enough to support the previous report that topical papaverine application can lead to transient facial nerve dysfunction.…”
Section: Discussionsupporting
confidence: 66%
“…4,10,[15][16][17] As with intracisternal application, all side effects were transient and reversible within 24 hours. Papaverine (6,7-dimethoxy-1-vera-trylisoquinoline) is an alkaloid extracted from the unripe seed capsules of the poppy plant, Papaver somniferum.…”
Section: Discussionmentioning
confidence: 95%
See 2 more Smart Citations
“…Papaverine is the most widely studied IA vasodilator. The administration of papaverine is associated with short-lived (roughly 3 h) effects on both vessel caliber and CBF, and multiple side effects, including brainstem depression, elevated intracranial pressure, seizures, hypotension, and occasionally paradoxical worsening of vasospasm [68,69]. Intracranial hypertension occurs in ≤42% of cases and may be associated with death and poor outcome [70][71][72][73].…”
Section: Endovascular Therapiesmentioning
confidence: 99%