Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T

Li, Xiaojuan; Youngren, Jack; Hyun, Ben; Sakkas, Giorgos K.; Mulligan, Kathleen; Majumdar, Sharmila; Masharani, Umesh; Schambelan, Morris; Goldfine, Ira D.

doi:10.1016/j.mri.2007.06.006

Cited by 28 publications

(21 citation statements)

References 36 publications

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“…). As previously described, the peaks were fitted to obtain their line widths and areas. MRS analyses were performed with automated fitting and quantification software.…”

Section: Methodsmentioning

confidence: 99%

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

Patsch

Baum

et al. 2013

Journal of Bone and Mineral Research

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The goal of this MR-imaging study was to quantify vertebral bone marrow fat content and composition in diabetic and non-diabetic postmenopausal women with fragility fractures and to compare them with non-fracture controls with and without type-2 diabetes mellitus. Sixty-nine postmenopausal women (mean age 63±5 years) were recruited. Thirty-six patients (47.8%) had spinal and/or peripheral fragility fractures. Seventeen fracture patients were diabetic. Thirty-three women (52.2%) were non-fracture controls. Sixteen women were diabetic non-fracture controls. To quantify vertebral bone marrow fat content and composition, patients underwent MR-spectroscopy (MRS) of the lumbar spine at 3 Tesla. Bone mineral density (BMD) was determined by dual-energy X-Ray-absorptiometry (DXA) of the hip and lumbar spine (LS) and quantitative computed tomography (QCT) of the LS. To evaluate associations of vertebral marrow fat content and composition with spinal and/or peripheral fragility fractures and diabetes, we used linear regression models adjusted for age, race, and spine vBMD by QCT. At the LS, non-diabetic and diabetic fracture patients had lower vBMD than controls and diabetics without fractures (p=0.018; p=0.005). However, aBMD by DXA did not differ between fracture and non-fracture patients. After adjustment for age, race, and spinal vBMD, the prevalence of fragility fractures was associated with -1.7% lower unsaturation levels (confidence interval [CI] -2.8% to - 0.5%, p=0.005) and +2.9% higher saturation levels (CI 0.5% to 5.3%, p=0.017). Diabetes was associated with -1.3% (CI -2.3% to -0.2%, p=0.018) lower unsaturation and +3.3% (CI 1.1% to 5.4%. p=0.004) higher saturation levels. Diabetics with fractures had the lowest marrow unsaturation and highest saturation. There were no associations of marrow fat content with diabetes or fracture. Our results suggest that altered bone marrow fat composition is linked with fragility fractures and diabetes. MRS of spinal bone marrow fat may therefore serve as a novel tool for BMD-independent fracture risk assessment.

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“…). As previously described, the peaks were fitted to obtain their line widths and areas. MRS analyses were performed with automated fitting and quantification software.…”

Section: Methodsmentioning

confidence: 99%

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

Patsch

Baum

et al. 2013

Journal of Bone and Mineral Research

Self Cite

296

283

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show abstract

“…Using methods previously described, the four peaks were fitted with Voigt models to estimate their areas and line widths (Fig. 4) (16–19). Bone marrow fat content (FC) of each vertebra was calculated according to the equation: FC = [(UL+SL+RL)/(UL+SL+RL+W)] × 100% where UL, SL, RL, and W are the areas of unsaturated lipids, saturated lipids, residual lipids, and water, respectively.…”

Section: Methodsmentioning

confidence: 99%

Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?

Baum

Yap

Karampinos

et al. 2011

Magnetic Resonance Imaging

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Purpose To compare vertebral bone marrow fat content quantified with proton MR spectroscopy (1H-MRS) with the volume of abdominal adipose tissue, lumbar spine volumetric bone mineral density (vBMD), and blood biomarkers in postmenopausal women with and without type 2 diabetes mellitus (T2DM). Materials and Methods Thirteen postmenopausal women with T2DM and 13 age- and BMI-matched healthy controls were included in this study. All subjects underwent 1H-MRS of L1–L3 to quantify vertebral bone marrow fat content (FC) and unsaturated lipid fraction (ULF). QCT was performed to assess vBMD of L1–L3. The volumes of abdominal subcutaneous/visceral/total adipose tissue were determined from the QCT images and adjusted for abdominal body volume (SATadj/VATadj/TATadj). Fasting blood tests included plasma glucose and HbA1c. Results Mean FC showed an inverse correlation with vBMD (r=−0.452; p<0.05) in the whole study population. While mean FC was similar in the diabetic women and healthy controls (69.3 ± 7.5% vs. 67.5 ± 6.1%; p>0.05), mean ULF was significantly lower in the diabetic group (6.7 ± 1.0% vs. 7.9 ± 1.6%; p<0.05). SATadj and TATadj correlated significantly with mean FC in the whole study population (r=0.538 and r=0.466; p<0.05). In contrast to the control group, significant correlations of mean FC with VATadj and HbA1c were observed in the diabetic group (r=0.642 and r=0.825; p<0.05). Conclusion This study demonstrated that vertebral bone marrow fat content correlates significantly with SATadj, TATadj, and lumbar spine vBMD in postmenopausal women with and without T2DM, but with VATadj and HbA1c only in women with T2DM.

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“…26, 27, 28 Each guinea pig was anesthetized using an induction protocol of intraperitoneal injection of medetomidine (0.25 mg kg −1 ) followed by inhalation of 4% isoflurane in O 2 . The concentration of isoflurane was decreased to 2.5–3% for maintenance of anesthesia during the imaging session.…”

Section: Methodsmentioning

confidence: 99%

Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring

et al. 2012

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Background:Ethanol consumption during pregnancy can lead to a range of adverse developmental outcomes in children, termed fetal alcohol spectrum disorder (FASD). Central nervous system injury is a debilitating and widely studied manifestation of chronic prenatal ethanol exposure (CPEE). However, CPEE can also cause structural and functional deficits in metabolic pathways in offspring.Objectives and Methods:This study tested the hypothesis that CPEE increases whole-body adiposity and disrupts pancreatic structure in guinea pig offspring. Pregnant guinea pigs received ethanol (4 g kg−1 maternal body weight per day) or isocaloric-sucrose/pair-feeding (control) for 5 days per week throughout gestation.Results:Male and female CPEE offspring demonstrated growth restriction at birth, followed by a rapid period of catch-up growth before weaning (postnatal day (PD) 1–7). Whole-body magnetic resonance imaging (MRI) in young adult offspring (PD100–140) revealed increased visceral and subcutaneous adiposity produced by CPEE. At the time of killing (PD150–200), CPEE offspring also had increased pancreatic adipocyte area and decreased β-cell insulin-like immunopositive area, suggesting reduced insulin production and/or secretion from pancreatic islets.Conclusion:CPEE causes increased adiposity and pancreatic dysmorphology in offspring, which may signify increased risk for the development of metabolic syndrome and type 2 diabetes mellitus.

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Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T

Cited by 28 publications

References 36 publications

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?

Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring

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