“…This approach allows to distribute multiple theranostic implants along the GI tract for the monitoring and treatment of therapy-refractory multisegmental motility disorders. 5 Figure 1.The current theranostic device design comprises a baseplate to integrate sensing and stimulation electrodes and 3 eyelets positioned at an orientation of 120° to allow suture fixation.…”
Section: Needmentioning
confidence: 99%
“…This approach allows to distribute multiple theranostic implants along the GI tract for the monitoring and treatment of therapy-refractory multisegmental motility disorders. 5 To evaluate a potential benefit of theranostic device placement, a minimally invasive analysis of GI segments is essential. The aim of this study was to evaluate a laparoscopic setup for electromyography (EMG) analysis and ES of the GI tract for future multisegmental implantation of several theranostic devices.…”
Need Electrical stimulation (ES) is a promising therapy for multisegmental gastrointestinal (GI) motility disorders such as gastroparesis with slow-transit constipation or chronic intestinal pseudo-obstruction. Wireless communicating GI devices for smart sensing and ES-based motility modulation will soon be available. Before placement, a potential benefit for each GI segment must be intraoperatively assessed. Technical Solution A minimally invasive multisegmental electromyography (EMG) analysis with ES of the GI tract is required. Proof of Concept Two porcine experiments were performed with a laparoscopic setup. Multiple hook-needle electrodes were subserosally applied in the stomach, duodenum, jejunum, ileum, and colon. EMG signals were acquired for computer-assisted motility analysis. Gastric ES, duodenal ES, jejunal ES, ileal ES, and colonic ES were applied. Next Steps Further technological and rapid regulatory solutions are desired to initialize a clinical trial of the next generation devices in the near future. Conclusion We demonstrate a laparoscopic strategy with EMG analysis and ES of multiple GI segments. Thus, GI function may be evaluated before theranostic devices are placed. Extended GI resection or organ transplantation may be delayed or even avoided in affected patients.
“…This approach allows to distribute multiple theranostic implants along the GI tract for the monitoring and treatment of therapy-refractory multisegmental motility disorders. 5 Figure 1.The current theranostic device design comprises a baseplate to integrate sensing and stimulation electrodes and 3 eyelets positioned at an orientation of 120° to allow suture fixation.…”
Section: Needmentioning
confidence: 99%
“…This approach allows to distribute multiple theranostic implants along the GI tract for the monitoring and treatment of therapy-refractory multisegmental motility disorders. 5 To evaluate a potential benefit of theranostic device placement, a minimally invasive analysis of GI segments is essential. The aim of this study was to evaluate a laparoscopic setup for electromyography (EMG) analysis and ES of the GI tract for future multisegmental implantation of several theranostic devices.…”
Need Electrical stimulation (ES) is a promising therapy for multisegmental gastrointestinal (GI) motility disorders such as gastroparesis with slow-transit constipation or chronic intestinal pseudo-obstruction. Wireless communicating GI devices for smart sensing and ES-based motility modulation will soon be available. Before placement, a potential benefit for each GI segment must be intraoperatively assessed. Technical Solution A minimally invasive multisegmental electromyography (EMG) analysis with ES of the GI tract is required. Proof of Concept Two porcine experiments were performed with a laparoscopic setup. Multiple hook-needle electrodes were subserosally applied in the stomach, duodenum, jejunum, ileum, and colon. EMG signals were acquired for computer-assisted motility analysis. Gastric ES, duodenal ES, jejunal ES, ileal ES, and colonic ES were applied. Next Steps Further technological and rapid regulatory solutions are desired to initialize a clinical trial of the next generation devices in the near future. Conclusion We demonstrate a laparoscopic strategy with EMG analysis and ES of multiple GI segments. Thus, GI function may be evaluated before theranostic devices are placed. Extended GI resection or organ transplantation may be delayed or even avoided in affected patients.
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