Technical note: an improved method for extraction and quantification of toxic phenethylamines from Acacia berlandieri

Pemberton, I. J.; Smith, Gerald R.; Forbes, T. D. A.; Hensarling, C.M.

doi:10.2527/1993.712467x

“…The NMT was originally believed to be one of the toxins in Acacia species and other plants that caused locomotor ataxia in sheep and goats (Pemberton et al ., ; Clement et al ., ). However, subsequent studies have shown that it is not responsible for toxicity in ruminants (Bourke et al ., ).…”

Section: Introductionmentioning

confidence: 99%

A Review of the Receptor Binding and Pharmacological Effects of N‐methyltyramine

Stohs

¹

,

Hartman²

2014

Phytotherapy Research

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N-methyltyramine (NMT) is a protoalkaloid isolated from various plant species. It is assumed that NMT is an adrenergic agonist with pharmacological properties similar to other structurally related biogenic amines. Current research studies indicate that NMT is an α-adrenoreceptor antagonist, and exhibits modest inhibitory (antagonistic) activity with respect to the breakdown of fats (lipolysis). Furthermore, NMT has been shown to enhance appetite and digestion of foods through its stimulatory effects on gastrin and pancreatic secretions. As a consequence, NMT is not an ingredient that should be used in dietary supplements designed to promote weight loss. It may result in an increase in perceived energy by promoting appetite and the digestion and absorption of nutrients while inhibiting the breakdown to fats to energy.

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“…Amine analyses were conducted at the Texas A&M Agricultural Experiment Station in Uvalde, Texas following extraction and analysis procedures of Pemberton et al (1993). Briefly, 1 g of ground material was added to 20 ml 1 % glacial acetic acid and extracted overnight on a rotary shaker followed by filtering through filter paper to remove solid plant tissue.…”

Section: Methodsmentioning

confidence: 99%

Effects of Aeration on Phenolic Amine Content of Guajillo

Windels¹,

Hewitt²,

Forbes³

2003

Journal of Range Management

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Aeration is a common range management technique used in southern Texas and northern Mexico to reduce shrub cover and increase biomass of more palatable forages. Guajillo (Acacia berlandieri Benth.) is an important forage plant for deer and domestic livestock throughout its range in northeastern Mexico and southern Texas. It responds to top removal, such as by aeration, by producing large numbers of juvenile sprouts which can have higher total leaf nitrogen content up to 6 months after treatment. However, the concentration of phenolic amines, potentially toxic secondary plant chemicals, may also increase. We compared concentrations of tyramine and N-methyl-phenethylamine (NMP), 2 prominent phenolic amines that can negatively affect reproduction in herbivores, between juvenile (regrowth) and mature stems of guajillo in areas that had been aerated and also between mature stems in aerated and control sites. Aeration increased NMP but not tyramine concentrations in mature stems. Juvenile stems had higher total nitrogen concentration than mature stems but also had higher amine concentrations until about 1 year after aeration. A greater percent of total nitrogen was incorporated into amines in juvenile stems (2.5-6.0%) than mature stems (1.8-4.2%). Amine concentrations peaked in summer and early autumn, a period when herbivores may rely heavily on browse because forbs are scarce. Our results suggest that while aeration may result in higher nitrogen concentrations in guajillo, increases in amines may limit benefits to herbivores.

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“…When consumed at even low concentrations, phenolic amines can have severe physiological effects on domestic livestock, such as reduced reproductive performance (Forbes et al 1993, 1994, Vera-Avila et al 1996, 1997). Forbes et al (1995) found that tyramine and N-methyl-phenethylamine (NMP) concentrations significantly increased in regrowth guajillo after simulated browsing.…”

Section: Introductionmentioning

confidence: 99%

Effects of aeration on phenolic amine content of guajillo

Windels¹,

Hewitt²,

Forbes³

2003

REM

View full text Add to dashboard Cite

Aeration is a common range management technique used in southern Texas and northern Mexico to reduce shrub cover and increase biomass of more palatable forages. Guajillo (Acacia berlandieri Benth.) is an important forage plant for deer and domestic livestock throughout its range in northeastern Mexico and southern Texas. It responds to top removal, such as by aeration, by producing large numbers of juvenile sprouts which can have higher total leaf nitrogen content up to 6 months after treatment. However, the concentration of phenolic amines, potentially toxic secondary plant chemicals, may also increase. We compared concentrations of tyramine and N-methyl-phenethylamine (NMP), 2 prominent phenolic amines that can negatively affect reproduction in herbivores, between juvenile (regrowth) and mature stems of guajillo in areas that had been aerated and also between mature stems in aerated and control sites. Aeration increased NMP but not tyramine concentrations in mature stems. Juvenile stems had higher total nitrogen concentration than mature stems but also had higher amine concentrations until about 1 year after aeration. A greater percent of total nitrogen was incorporated into amines in juvenile stems (2.5-6.0%) than mature stems (1.8-4.2%). Amine concentrations peaked in summer and early autumn, a period when herbivores may rely heavily on browse because forbs are scarce. Our results suggest that while aeration may result in higher nitrogen concentrations in guajillo, increases in amines may limit benefits to herbivores.

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Technical note: an improved method for extraction and quantification of toxic phenethylamines from Acacia berlandieri

Cited by 12 publications

References 0 publications

A Review of the Receptor Binding and Pharmacological Effects of N‐methyltyramine

A Review of the Receptor Binding and Pharmacological Effects of N‐methyltyramine

Effects of Aeration on Phenolic Amine Content of Guajillo

Effects of aeration on phenolic amine content of guajillo

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